GHK-Cu

Common questions about GHK-Cu

What is GHK-Cu and what does it do?

GHK-Cu is a copper-binding tripeptide (glycyl-L-histidyl-L-lysine bound to copper) that occurs naturally in human plasma. Plasma levels decline with age (approximately 60 percent reduction between ages 20 and 60). The peptide signals tissue remodeling, collagen and elastin synthesis, and gene expression linked to wound repair. Published microarray studies document GHK-Cu effects across thousands of human genes related to repair pathways. The GHK-Cu vial a licensed U.S. 503A compounding pharmacy compounds for Rx Peps Direct prescriptions is 50 mg at $80 with a $39 medical review.

How much GHK-Cu should I inject daily?

The Rx Peps Direct dose is 20 units (2 mg) on a U-100 insulin syringe drawn from the 50 mg vial (which ships pre-reconstituted at 10 mg/mL), injected once daily Monday to Friday, which is 5 days on and 2 days off. Protocols described elsewhere deliver 1 to 3 mg per day subcutaneously. Higher doses are not associated with better outcomes in available studies and may increase the chance of injection-site reactions. Your provider sets the protocol based on the intended outcome (skin, wound healing, recovery support).

Where to inject GHK-Cu?

GHK-Cu is injected subcutaneously into the abdomen, upper outer thigh, or back of the upper arm. For a localized cosmetic or wound goal, inject as close to the target tissue as safely possible because the peptide acts strongly at the local level. Use a 31-gauge, 5/16-inch (8 mm) needle on a U-100 insulin syringe. Rotate sites between injections.

How long does GHK-Cu take to work?

Skin and connective-tissue effects build over 4 to 12 weeks of consistent use. Wound and post-procedural recovery patients often see accelerated healing within the first 7 to 14 days. Hair-related applications (some studies suggest follicle stimulation) typically need 12 to 16 weeks before measurable change. Onset varies with age, baseline tissue health, and protocol consistency.

Do I have to reconstitute GHK-Cu myself?

No. The 50 mg GHK-Cu vial a licensed U.S. 503A compounding pharmacy ships for Rx Peps Direct prescriptions is already reconstituted at 10 mg/mL and ready to inject. At that concentration, 20 units (0.2 mL) on a U-100 insulin syringe equals 2 mg per dose. You do not need to mix anything, supply bacteriostatic water, or wait for the powder to dissolve. This is a structural difference from research-grade GHK-Cu sold as a lyophilized powder, where the user has to source bac water separately (currently on national shortage) and reconstitute by hand.

Can I use GHK-Cu topically for skin?

Topical GHK-Cu serums are widely available but they deliver a much lower concentration to the dermis than subcutaneous injection because the peptide does not readily cross intact skin. The GHK-Cu a licensed U.S. 503A compounding pharmacy compounds is a sterile injectable intended for subcutaneous administration; do not pour the injectable solution onto skin or use it cosmetically. If your goal is purely cosmetic skin support, a separate topical GHK-Cu product is more appropriate; ask your provider for guidance.

Is GHK-Cu safe long-term?

GHK-Cu is endogenous to human plasma and has no documented long-term toxicity at therapeutic doses. The most common adverse effects are mild injection-site reactions and rare transient flushing. Patients with copper allergy should avoid GHK-Cu. Patients with Wilson's disease or other copper-metabolism disorders should not use it. Your Rx Peps Direct provider screens for these conditions during intake.