Epithalon
Activates telomerase to maintain telomere length, potentially slowing cellular aging at the chromosomal level.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.What It Is
Epithalon (Epitalon) is a synthetic version of the naturally-occurring Epithalamin peptide produced by the pineal gland. It's the most studied telomerase activator.
How It Works
It activates the enzyme telomerase, which adds protective sequences to the ends of chromosomes (telomeres). Longer telomeres are associated with younger cellular age.
Who It's For
Anyone interested in fundamental longevity science. Those looking to support cellular health at the most basic level. Chromosomal integrity.
Who Should Avoid It
Generally well-tolerated. Discuss with provider if you have hormone-sensitive conditions.
Protocol & Pricing
OBP Pharmacy Price
$80/10mg
You pay pharmacy price. No markup.
Starting Dose
25 units (0.5mg)
Form
Injectable vial (5mL, 2mg/mL, 10mg total)
Dosing Protocol
25 units subcutaneous injection daily, Monday–Friday. 25 units = 0.25mL × 2mg/mL = 0.5mg per injection. 8–12 weeks duration, may be cycled or extended.
Beyond Use Date
90 Days from compounding (USP <797>)
Use within this window from the date your vial is compounded. BUD is set per USP <797> sterile compounding standards and printed on every label.
Stacking Guide
Stacks Well With
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$80/10mgCommon questions about Epithalon
- What is epithalon?
- Epithalon (also spelled epitalon) is a 4-amino acid synthetic peptide developed in Russia in the 1980s as a synthetic equivalent of an active fragment of the pineal-gland hormone epithalamin. It is studied for telomere lengthening, melatonin restoration in older adults, and overall geroprotective (anti-aging) effects. Most published efficacy data is from Russian and Eastern European research; large-scale Western clinical trial data is limited.
- Does epithalon really lengthen telomeres or extend lifespan?
- Animal studies (mostly rodent) consistently show telomerase activation and small extensions of mean lifespan with epithalon administration. Human studies are limited and show various outcomes around immune markers, melatonin secretion, and biomarkers of aging. Whether those effects translate to clinically meaningful longevity in humans is unproven. Use is investigational and supervised by the prescribing provider.
- How is epithalon dosed?
- Common subcutaneous protocols deliver 5 to 10 mg per day for 10 to 20 consecutive days, repeated every 6 months. The pulsed dosing pattern is intended to mimic the brief, episodic nature of natural pineal signaling rather than continuous receptor stimulation. Optimal Balance Pharmacy compounds epithalon against PeptideRx prescriptions; your provider sets the protocol.
- How do I run an epithalon protocol?
- A common pattern is 10 mg subcutaneously every other day for a 10-injection course, repeated twice yearly. Some protocols use daily dosing for 10 to 20 consecutive days. Most providers prefer the pulsed approach. Subcutaneous injection into the abdomen, upper outer thigh, or back of the upper arm using a 31-gauge insulin syringe.
- How is epithalon supplied?
- Compounded by Optimal Balance Pharmacy under a 503A patient-specific prescription. Ships pre-reconstituted and ready to inject in cold-chain packaging. Every batch is tested by Eagle Analytical Services for sterility and bacterial endotoxin; the Certificate of Analysis is published on this product page.