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Epithalon

Activates telomerase to maintain telomere length, potentially slowing cellular aging at the chromosomal level.

Dr. Jonathan Snipes, MDMedically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
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Epithalon dispensed by a licensed U.S. 503A compounding pharmacy

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Telomere SupportCellular Anti-AgingPineal SupportSleep Quality

What It Is

Epithalon (Epitalon) is a synthetic version of the naturally-occurring Epithalamin peptide produced by the pineal gland. It's the most studied telomerase activator.

How It Works

It activates the enzyme telomerase, which adds protective sequences to the ends of chromosomes (telomeres). Longer telomeres are associated with younger cellular age.

Who It's For

Anyone interested in fundamental longevity science. Those looking to support cellular health at the most basic level. Chromosomal integrity.

Who Should Avoid It

Generally well-tolerated. Discuss with provider if you have hormone-sensitive conditions.

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Protocol & Pricing

Pharmacy Price

$80

2mg/mL, 5mL vial (10mg total)

You pay pharmacy price. No markup.

Starting Dose

25 units (0.5mg)

Form

Injectable vial, 5mL

Your pharmacy label will read

EPITHALON

2 MG/ML (5 ML)

The label shows strength per mL, not the total in the vial.

What that means

  • 2mg/mL means 2mg in every mL.
  • The vial holds 5mL, so 2mg/mL × 5mL = 10mg in the vial.
  • Each 25-unit injection (0.25mL) gives you 0.5mg, about 20 injections per vial.

Dosing Protocol

25 units subcutaneous injection daily, Monday to Friday. 25 units = 0.25mL × 2mg/mL = 0.5mg per injection. 8 to 12 weeks duration, may be cycled or extended.

Beyond Use Date

90 Days from compounding (USP <797>)

A licensed U.S. 503A compounding pharmacy assigns this date and prints it on your vial label. Always follow the label.

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Stacking Guide

Stacks Well With

GHK-CuNAD+ InjectableMOTS-C

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Longevity peptide protocol

Read the Epithalon protocol guide

Pineal tetrapeptide, telomerase reactivation, the in vitro telomere result, the 266-patient extract trial, fly and mouse lifespan data, WADA S0 status, and the 503A pathway. Honest about how thin and unreplicated the human proof is.

Read guide

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Independently tested

Epithalon certificate of analysis

All 2 Epithalon samples tested for sterility and endotoxin passed both. Latest sample received by the lab Oct 2, 2026.

Every Epithalon batch dispensed by a licensed U.S. 503A compounding pharmacy is independently tested by Eagle Analytical Services (FDA-registered, A2LA ISO 17025 accredited). Sterility testing checks that nothing grows in the sample; the USP <85> endotoxin test checks for bacterial toxins that can cause fever. Below is the lab's own report for each of the 2 most recent lots.

Lot LG342011054, received Oct 2, 2026

Sterility
PassScanRDI Sterility Test. Started Oct 2, 2026, completed Oct 6, 2026. Method suitability ETX-251231-0448
Bacterial endotoxin
PassUSP <85>. Measured <2 EU/mL, limit 350 EU/mL. Started Oct 6, 2026, completed Oct 6, 2026
Sample, as printed
EPITHALION 2 MG/ML (5 ML) Injection
Lot #
LG342011054
Storage
Refrigerated
Received by lab
Oct 2, 2026
Laboratory
Eagle Analytical Services Inc., Houston, TX
Submission #
ETX-261002-0351
Signed
Alison Eng, Quality Control Manager
Scan of Eagle Analytical report ETX-261002-0351 for lot LG342011054. Opens the original PDF.
Eagle Analytical report ETX-261002-0351. Open the original PDF (opens in a new tab)

Eagle Analytical Services is an independent FDA-registered laboratory, A2LA accredited to ISO 17025, based in Houston, Texas. They have no commercial relationship with Rx Peps Direct. Rx Peps Direct prescribes; the pharmacy compounds and dispenses; Eagle tests every batch. Three separate companies. Results apply only to the tested sample as received. Browse our full quality program on the quality page.

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How to get Epithalon prescribed online

Epithalon is available by prescription after an online medical review and dispensed for human use by a licensed 503A pharmacy. That is what separates it from research-use-only vials sold without a prescription. There is no membership, just a medical review fee per order, and automatic refills are optional.

  1. 1

    Complete a $39 medical review. Answer a short intake about your health history and your goals for Epithalon. The $39 fee is the only charge Rx Peps Direct collects, paid once, not a recurring subscription.

  2. 2

    A licensed provider reviews it. A US-licensed clinician reviews your intake and, if Epithalon is appropriate for you, writes a patient-specific prescription. The starting dose is typically 25 units (0.5mg).

  3. 3

    The pharmacy compounds and ships it. A licensed 503A compounding pharmacy in Texas compounds Epithalon and ships it pre-reconstituted by FedEx overnight in a reusable cooled case. Your fill is a 5mL injectable vial at 2mg/mL (10mg total), labeled "EPITHALON 2 MG/ML (5 ML)", and you pay the pharmacy $80 per vial at wholesale, with no clinic markup, plus a $15 flat FedEx overnight shipping fee charged by the pharmacy.

Rx Peps Direct prescribes Epithalon in the 28 states plus Washington, DC where its medical team is licensed. Start your $39 medical review or browse the full Longevity & Anti-Aging range. Comparing services first? See how Rx Peps Direct stacks up against seven other providers in our best telehealth for compounded peptides comparison.

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Common questions about Epithalon

What is epithalon?
Epithalon (also spelled epitalon) is a 4-amino acid synthetic peptide developed in Russia in the 1980s as a synthetic equivalent of an active fragment of the pineal-gland hormone epithalamin. It is studied for telomere lengthening, melatonin restoration in older adults, and overall geroprotective (anti-aging) effects. Most published efficacy data is from Russian and Eastern European research; large-scale Western clinical trial data is limited.
Does epithalon really lengthen telomeres or extend lifespan?
Animal studies (mostly rodent) consistently show telomerase activation and small extensions of mean lifespan with epithalon administration. Human studies are limited and show various outcomes around immune markers, melatonin secretion, and biomarkers of aging. Whether those effects translate to clinically meaningful longevity in humans is unproven. Use is investigational and supervised by the prescribing provider.
How is epithalon dosed?
Common subcutaneous protocols deliver 5 to 10 mg per day for 10 to 20 consecutive days, repeated every 6 months. The pulsed dosing pattern is intended to mimic the brief, episodic nature of natural pineal signaling rather than continuous receptor stimulation. A licensed U.S. 503A compounding pharmacy compounds epithalon against Rx Peps Direct prescriptions; your provider sets the protocol.
How do I run an epithalon protocol?
A common pattern is 10 mg subcutaneously every other day for a 10-injection course, repeated twice yearly. Some protocols use daily dosing for 10 to 20 consecutive days. Most providers prefer the pulsed approach. Subcutaneous injection into the abdomen, upper outer thigh, or back of the upper arm using a 31-gauge insulin syringe.
How is epithalon supplied?
Compounded by a licensed U.S. 503A compounding pharmacy under a patient-specific prescription. Ships pre-reconstituted and ready to inject in cold-chain packaging. Every batch is tested by Eagle Analytical Services for sterility and bacterial endotoxin; the Certificate of Analysis is published on this product page.

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A licensed provider reviews every order.