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MOTS-C

A mitochondrial-encoded peptide that activates AMPK and regulates metabolic homeostasis.

Dr. Jonathan Snipes, MDMedically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
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MOTS-C dispensed by a licensed U.S. 503A compounding pharmacy

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Mitochondrial HealthMetabolic SupportExercise CapacityAMPK Activation

What It Is

MOTS-C is a peptide encoded within the mitochondrial genome. It's one of the few known 'mitochondrial-derived peptides' and plays a key role in metabolic regulation.

How It Works

It activates AMPK (the cellular energy sensor), regulates glucose and fat metabolism, and has been shown to improve exercise capacity and metabolic flexibility.

Who It's For

Those interested in metabolic health optimization and mitochondrial function. Particularly relevant for age-related metabolic decline.

Who Should Avoid It

Generally well-tolerated. Discuss with provider if diabetic.

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Protocol & Pricing

Pharmacy Price

$80

2mg/mL, 5mL vial (10mg total)

You pay pharmacy price. No markup.

Starting Dose

20 units (0.4mg)

Form

Injectable vial, 5mL

Your pharmacy label will read

MOTs-C

2 MG/ML (5 ML)

The label shows strength per mL, not the total in the vial.

What that means

  • 2mg/mL means 2mg in every mL.
  • The vial holds 5mL, so 2mg/mL × 5mL = 10mg in the vial.
  • Each 20-unit injection (0.2mL) gives you 0.4mg, about 25 injections per vial.

Dosing Protocol

Inject 20 units subcutaneously three times per week, preferably on consistent days, or 30 to 60 minutes before your workout on three training days each week. 20 units = 0.2mL × 2mg/mL = 0.4mg per injection. Store at room temperature.

Beyond Use Date

90 Days from compounding (USP <797>)

A licensed U.S. 503A compounding pharmacy assigns this date and prints it on your vial label. Always follow the label.

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A licensed provider reviews every order.

Stacking Guide

Stacks Well With

NAD+ InjectableEpithalonElamipretide (SS-31)

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A licensed provider reviews every order.

Mitochondrial-derived peptide (metabolic)

Read the MOTS-C protocol guide

Strong rodent data, thin human RCT data. AMPK activator (different mechanism than metformin). WADA prohibited since 1/1/2025. Not an exercise substitute.

Read guide

Related Peptides

NAD+ Injectable

The cellular energy molecule. Injectable NAD+ for direct bioavailability and cellular rejuvenation.

$100 · 100mg/mL, 10mL vial (1000mg total)

Epithalon

A telomerase-activating peptide that may help maintain telomere length. A key marker of cellular aging.

$80 · 2mg/mL, 5mL vial (10mg total)

Elamipretide (SS-31)

A mitochondria-targeted peptide that stabilizes the inner membrane for optimal energy production.

$100 · 15mg/mL, 5mL vial (75mg total)

Independently tested

MOTS-C certificate of analysis

All 2 MOTS-C samples tested for sterility and endotoxin passed both. Latest sample received by the lab Sep 29, 2026.

Every MOTS-C batch dispensed by a licensed U.S. 503A compounding pharmacy is independently tested by Eagle Analytical Services (FDA-registered, A2LA ISO 17025 accredited). Sterility testing checks that nothing grows in the sample; the USP <85> endotoxin test checks for bacterial toxins that can cause fever. Below is the lab's own report for each of the 2 most recent lots.

Lot LG342010959, received Sep 29, 2026

Sterility
PassCelsis Sterility Test. Started Sep 29, 2026, completed Oct 7, 2026. Method suitability ETX-260112-0497
Bacterial endotoxin
PassUSP <85>. Measured <2 EU/mL, limit 1400 EU/mL. Started Sep 30, 2026, completed Oct 1, 2026
Sample, as printed
MOTs-C 2 MG/ML (5 ML) Injection
Lot #
LG342010959
Storage
Refrigerated
Received by lab
Sep 29, 2026
Laboratory
Eagle Analytical Services Inc., Houston, TX
Submission #
ETX-260929-0232
Signed
Alison Eng, Quality Control Manager
Scan of Eagle Analytical report ETX-260929-0232 for lot LG342010959. Opens the original PDF.
Eagle Analytical report ETX-260929-0232. Open the original PDF (opens in a new tab)

Eagle Analytical Services is an independent FDA-registered laboratory, A2LA accredited to ISO 17025, based in Houston, Texas. They have no commercial relationship with Rx Peps Direct. Rx Peps Direct prescribes; the pharmacy compounds and dispenses; Eagle tests every batch. Three separate companies. Results apply only to the tested sample as received. Browse our full quality program on the quality page.

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How to get MOTS-C prescribed online

MOTS-C is available by prescription after an online medical review and dispensed for human use by a licensed 503A pharmacy. That is what separates it from research-use-only vials sold without a prescription. There is no membership, just a medical review fee per order, and automatic refills are optional.

  1. 1

    Complete a $39 medical review. Answer a short intake about your health history and your goals for MOTS-C. The $39 fee is the only charge Rx Peps Direct collects, paid once, not a recurring subscription.

  2. 2

    A licensed provider reviews it. A US-licensed clinician reviews your intake and, if MOTS-C is appropriate for you, writes a patient-specific prescription. The starting dose is typically 20 units (0.4mg).

  3. 3

    The pharmacy compounds and ships it. A licensed 503A compounding pharmacy in Texas compounds MOTS-C and ships it pre-reconstituted by FedEx overnight in a reusable cooled case. Your fill is a 5mL injectable vial at 2mg/mL (10mg total), labeled "MOTs-C 2 MG/ML (5 ML)", and you pay the pharmacy $80 per vial at wholesale, with no clinic markup, plus a $15 flat FedEx overnight shipping fee charged by the pharmacy.

Rx Peps Direct prescribes MOTS-C in the 28 states plus Washington, DC where its medical team is licensed. Start your $39 medical review or browse the full Longevity & Anti-Aging range. Comparing services first? See how Rx Peps Direct stacks up against seven other providers in our best telehealth for compounded peptides comparison.

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A licensed provider reviews every order.

Common questions about MOTS-C

What is MOTS-c?
MOTS-c (mitochondrial-derived peptide, 16 amino acids) is a peptide encoded within the mitochondrial 12S rRNA gene. It plays a regulatory role in metabolic homeostasis, AMPK signaling, and insulin sensitivity. Levels decline with age. The peptide is studied for type 2 diabetes prevention, exercise-mimetic effects, body composition support, and longevity-related metabolic dysfunction.
Does MOTS-c improve metabolism and longevity?
Animal studies show MOTS-c administration improves insulin sensitivity, reduces visceral adiposity, and extends mean lifespan in mice. Small human studies suggest improved glucose tolerance and exercise performance markers. Long-term human longevity outcomes are not established. Use is supported by an evidence base that is stronger than many compounded peptides but still well short of FDA-approval standards.
How is MOTS-c dosed?
Common subcutaneous protocols deliver 5 to 10 mg per dose 2 to 3 times per week, run as 8 to 12 week courses with breaks. A licensed U.S. 503A compounding pharmacy compounds MOTS-c against Rx Peps Direct prescriptions; your provider sets the protocol based on your metabolic profile.
Where do I inject MOTS-c?
Subcutaneously into the abdomen, upper outer thigh, or back of the upper arm using a 31-gauge, 5/16-inch (8 mm) needle on a U-100 insulin syringe. Sterile syringes are included with every Rx Peps Direct shipment. Rotate sites between injections.
How is MOTS-c supplied?
Compounded by a licensed U.S. 503A compounding pharmacy under a patient-specific prescription. Ships pre-reconstituted and ready to inject in cold-chain packaging. Every batch is tested by Eagle Analytical Services for sterility and bacterial endotoxin; the Certificate of Analysis is published on this product page.

Ready to add MOTS-C?

A licensed provider reviews every order.