What It Is
Ondansetron is the generic name for Zofran®. The orally disintegrating tablet (ODT) form melts on the tongue, no water needed — useful when nausea is acute. Prescribed as an adjunct to GLP-1 therapy for patients who experience breakthrough nausea during dose titration.
How It Works
Ondansetron blocks serotonin (5-HT3) receptors in the gut and brain that trigger the nausea reflex. It does not treat nausea by sedating you — it interrupts the chemical signal directly.
Who It's For
Patients on semaglutide or tirzepatide who experience nausea during the first 4–8 weeks of titration, or whenever a dose increase brings it back. Use as needed, not on a schedule.
Who Should Avoid It
Avoid in patients with congenital long QT syndrome. Use caution with other QT-prolonging medications. Not for chronic daily use.
Protocol & Pricing
OBP Pharmacy Price
$37.50/30 tablets
You pay pharmacy price. No markup.
Starting Dose
1 tablet (4mg) every 8 hours as needed for nausea
Form
Orally disintegrating tablet (4mg × 30 tablets per pack)
Dosing Protocol
1 tablet (4mg) dissolved on the tongue every 8 hours as needed. Maximum 3 tablets per 24 hours. Take 30–60 minutes before a GLP-1 injection if nausea is anticipated. 30 tablets per fill, $37.50.
Stacking Guide
Stacks Well With
Related Peptides
Semaglutide/B12
The gold standard GLP-1 for weight management, paired with B12 for energy support.
From $25/1.2mgSemaglutide/B6 + Glycine
Glycine-buffered semaglutide for patients who don't tolerate the B12 cofactor.
From $175/10mgTirzepatide/B12
Dual GIP/GLP-1 receptor agonist for enhanced metabolic support with B12.
From $45/12mg