Tesofensine
Inhibits reuptake of norepinephrine, dopamine, and serotonin to reduce appetite and increase metabolism.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.What It Is
Tesofensine is a triple monoamine reuptake inhibitor originally developed for neurological conditions. It was found to have significant appetite-suppressing effects.
How It Works
By increasing levels of norepinephrine, dopamine, and serotonin in the brain, it naturally reduces hunger signals and can increase resting metabolic rate.
Who It's For
Adults who need additional appetite control support. Often prescribed when GLP-1 medications alone aren't sufficient or aren't suitable.
Who Should Avoid It
Not suitable for those with uncontrolled hypertension, cardiovascular disease, history of stroke, or anxiety disorders. Avoid with MAOIs.
Protocol & Pricing
OBP Pharmacy Price
$2.25/cap
You pay pharmacy price. No markup.
Starting Dose
500mcg/day
Form
Capsule (500mcg)
Dosing Protocol
1 capsule (500mcg) daily, taken in the morning. Do not exceed prescribed dose.
Beyond Use Date
180 Days from compounding (USP <797>)
Use within this window from the date your vial is compounded. BUD is set per USP <797> sterile compounding standards and printed on every label.
Stacking Guide
Stacks Well With
Do Not Combine With
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From $35/10mlCommon questions about Tesofensine
- What is tesofensine?
- Tesofensine is a triple monoamine reuptake inhibitor (norepinephrine, dopamine, serotonin) originally developed as an anti-Parkinson's and anti-Alzheimer's drug, where it failed efficacy endpoints but produced significant weight loss as a side effect. It has been studied in obesity trials and is approved for weight loss in some jurisdictions outside the United States (notably Mexico and parts of Latin America). It is not FDA-approved in the U.S.
- Is tesofensine an FDA-approved drug?
- No. Tesofensine is not FDA-approved in the United States. It is approved in Mexico and is used off-label in U.S. compounding telemedicine for weight management. As an investigational compound it is dispensed under a 503A patient-specific prescription with informed-consent intake.
- How is tesofensine dosed at PeptideRx?
- Common protocols start at 0.25 mg per day orally and titrate to 0.5 to 1 mg per day over several weeks based on tolerance. Tesofensine is taken once daily in the morning. Optimal Balance Pharmacy compounds the formulation against PeptideRx prescriptions; your provider sets the protocol based on your medical history.
- What are the side effects of tesofensine?
- Common side effects include dry mouth, insomnia (dose-dependent), elevated heart rate, anxiety, and reduced appetite (the mechanism). Tesofensine raises blood pressure modestly; patients with uncontrolled hypertension should not use it. Avoid combining with other monoamine-active medications (SSRIs, SNRIs, MAOIs, stimulants) without provider review. Do not stack with GLP-1s without provider clearance.
- How is tesofensine supplied?
- Dispensed by Optimal Balance Pharmacy in capsule form against PeptideRx prescriptions. Each batch is tested for potency; the Certificate of Analysis is published on this product page. Capsules ship at room temperature.