Best compounded semaglutide telehealth in 2026

Medically reviewed by Dr. Jonathan Snipes, MD and Kim Callender, NP, FNP-BC. Last reviewed May 15, 2026.

The short answer

Seven telehealth services prescribe compounded semaglutide direct to patients today. RxPepsDirect has the lowest starter dollar amount ($25 per 1.2mg vial plus a one-time $39 visit) in 33 states, with the full dose ladder published publicly. Peak Wellness is the cheapest flat monthly bundle at $149/month on the annual plan, with the same rate at every dose. Mochi Health at $178/month effective bundles dietitian support and group programming. Eden Health covers the widest geography (all 50 states) and runs its own in-house compounding pharmacy (Contigo, acquired August 2025). Henry Meds, ShedRx, and GobyMeds round out the field with subscription bundles that escalate as the dose climbs. Branded Wegovy and Ozempic prescribers (Ro, Calibrate, Form Health, and so on) are not on this list because they do not dispense compounded.

How we built this comparison

We checked every site on May 15, 2026. To make the list, a service has to publish compounded semaglutide on its public site (no account required) and bill cash-pay through a US 503A pharmacy. Branded semaglutide (Wegovy, Ozempic, Rybelsus) is a different product and is not counted. Effective monthly cost reflects what the patient actually pays end-to-end: medical visit fee plus medication. Per-unit cost is the lowest published starter dose where available.

Side-by-side comparison

1. RxPepsDirect

Best for: the lowest starter dollar amount and pay-per-vial economics with no subscription. $25 for a 1.2mg starter vial, $39 for the medical visit, pharmacy bills you at wholesale.

RxPepsDirect is a Denver, Colorado-based telehealth service that partners with Optimal Balance Pharmacy, a Texas 503A. Semaglutide comes in two formulations: Semaglutide/B-12 from $25 per 1.2mg vial and Semaglutide/Glycine from $175 per 10mg vial for patients who react to the B-12 cofactor. Both use the same active molecule as Wegovy and Ozempic. The full dose ladder is published with per-vial pricing so patients can plan the cost as they titrate up.

RxPepsDirect is the only service on this list that does not bundle. You pay $39 once for the medical visit; that is it from the clinic. Optimal Balance bills you separately for the medication at wholesale with no clinic markup. There is no subscription, no auto-refill, and no membership tier. Refills are patient-driven per vial.

• Starter price: $25 per 1.2mg vial (Semaglutide/B-12); $175 per 10mg vial (Semaglutide/Glycine)
• Full dose ladder (pharmacy passthrough, no markup): 1.2mg $25, 2.4mg $30, 4.4mg $42.68, 6.8mg $65.96, 8.2mg $79.54, 11.2mg $108.64, 12.5mg $121.25, 15mg $145.50, 20mg $194, 30mg $291
• Medical visit: $39 one-time per order
• States licensed: 33 (medical director Dr. Jonathan Snipes, NPI 1821250077)
• Pharmacy: Optimal Balance Pharmacy (503A, Texas)
• Lab testing: Eagle Analytical (sterility via ScanRDI, endotoxin per USP <85>, potency per USP <621>)
• Carrier options: B-12 (cyanocobalamin) or glycine plus B-6

The trade-off: 33-state coverage is narrower than Eden (~50) or Henry Meds (41), and the per-vial model does not bundle visits or supplies the way Peak Wellness or Mochi do. At high maintenance doses, the $291 30mg vial puts RxPepsDirect in the same ballpark as Peak Wellness ($149/mo flat) on a monthly basis, but patients still avoid the subscription lock-in. Semaglutide/B-12 product page or read how the two RxPepsDirect formulations compare.

2. Peak Wellness

Best for: patients who want one flat price and no surprise increase when their dose climbs. $149/month on the 12-month plan covers any dose from 0.25mg to 2.4mg.

Peak Wellness publishes the lowest flat monthly rate on this list. The 12-month annual plan is $149/month; the 6-month plan is $165/month; the month-to-month plan is $129/month. The same rate applies at every dose tier from 0.25mg through 2.4mg, which is unusual in the category and removes the dose-step pricing surprise that hits patients on Henry Meds, ShedRx, and GobyMeds.

The trade-off is what is not published. Peak Wellness does not name its compounding pharmacy partner on the public site and does not publish a licensed-state list. Both are gated until the intake step.

• Effective monthly cost: $149 on annual, $165 on 6-month, $129 on month-to-month
• Dose behavior: flat at every titration step from 0.25mg to 2.4mg
• States licensed: not published on the public site
• Pharmacy: state-licensed 503A pharmacy partner (not named publicly)

3. Mochi Health

Best for: patients who want a registered dietitian, lab review, and group support bundled with the medication, and live in one of the 10 states Mochi serves.

Mochi Health is GLP-1-first. The base membership is $79/month (with a $39 promotional first month) and compounded injectable semaglutide adds $99/month, for an effective cost of $178/month. That is significantly cheaper than the equivalent Mochi tirzepatide stack ($278/month) because the semaglutide molecule is less expensive to compound. The bundle includes registered dietitians, lab review, structured weight-loss curriculum, and ongoing provider check-ins.

The trade-off is geography. Mochi serves about 10 states (Arizona, Colorado, Florida, Georgia, Illinois, Massachusetts, Maryland, Minnesota, New York, Oregon). The pharmacy partner is not named publicly. Promotional pricing varies by state.

• Effective monthly cost: $178 ($79 base plus $99 semaglutide add-on)
• States licensed: ~10 (AZ, CO, FL, GA, IL, MA, MD, MN, NY, OR)
• Pharmacy: partner 503A pharmacy (not named publicly)
• Bundle includes: medication, dietitian access, lab review, group programming

4. Eden Health

Best for: the widest state coverage and a service that owns its own compounding pharmacy, with flat pricing across every dose.

Eden Health is the largest service on this list by geographic reach. The company states it can serve all 50 states for GLP-1 programs. In August 2025, Eden acquired Contigo Compounding, a 503A pharmacy, which now operates as Eden’s in-house fulfillment. That vertical integration lets Eden offer micro-titration doses and direct supply-chain control.

Pricing is flat across all doses. The 3-month plan is $129 for the first month then $209/month ongoing; the monthly plan is $149 first then $229/month. The trade-off is the up-front commitment; the 3-month price advantage only triggers if the patient stays the full window. Detailed RxPepsDirect vs Eden comparison.

• Effective monthly cost: $209/mo on 3-month plan ($129 first); $229/mo monthly ($149 first)
• Dose behavior: flat across all doses
• States licensed: all 50
• Pharmacy: Contigo Compounding (in-house, acquired August 2025)

5. Henry Meds

Best for: patients who want broad state coverage and oral semaglutide drops as an alternative to injection.

Henry Meds is one of the largest compounded GLP-1 telehealth services in the US. Injectable compounded semaglutide starts at $197/month on the 12-month prepay plan and climbs to about $297/month at maintenance dose; the month-to-month plan starts around $297 and reaches $397 at maintenance. Henry also offers oral semaglutide drops starting near $119/month for patients who want to avoid injection.

Coverage is 41 states (excludes AL, AK, AR, HI, LA, MS, MO, SC, WV). The pricing structure escalates roughly $100 per dose tier, which is the biggest single difference from Peak Wellness or Eden’s flat-rate model. The compounding pharmacy partner is not named on the public pricing page.

• Effective monthly cost: $197 to $297 on annual plan; $297 to $397 month-to-month
• Oral option: semaglutide drops from ~$119/month
• Dose behavior: ~$100 step-up per dose tier
• States licensed: 41 (excludes AL, AK, AR, HI, LA, MS, MO, SC, WV)
• Pharmacy: partner 503A pharmacy (not named publicly)

6. ShedRx

Best for: patients who want LegitScript-verified intake and a structured 2-month starter commitment.

ShedRx (tryshed.com) sells compounded semaglutide at $199/month on the starter dose and $299/month at higher titration tiers, with a 2-month minimum commitment. The site claims more than 150,000 members nationwide and carries a LegitScript verification seal, which signals third-party screening for telehealth compliance. The compounding pharmacy partner is not named on the public site.

• Effective monthly cost: $199 (starter) to $299 (higher dose)
• Minimum commitment: 2 months
• States licensed: not published on the public site
• Pharmacy: partner 503A pharmacy (not named)
• Compliance signal: LegitScript verified

7. GobyMeds

Best for: patients shopping by introductory price who can tolerate steep dose-step increases at maintenance.

GobyMeds publishes the lowest headline starter price at $99 per month, along with a $299 12-week starter bundle. The site discloses that pricing escalates at higher doses ($399 to $499 per month at maintenance), which is the steepest dose-step curve on this list. The compounding pharmacy partner is described as a 503A or 503B partner licensed in the patient’s state but is not named on the public site.

• Starter price: $99+/month, or $299 for the 12-week starter bundle
• Maintenance pricing: $399 to $499/month at higher doses
• Dose behavior: sharp escalation as the dose climbs
• States licensed: not published on the public site
• Pharmacy: 503A or 503B partner pharmacy (not named)

Why Ro, Hims, Calibrate, and Form Health aren’t on this list

You will see these names searching for semaglutide telehealth. They focus on branded GLP-1s (Wegovy, Ozempic, Rybelsus) rather than compounded semaglutide, which is a different product and a different price tier. Wegovy and Ozempic run $900 to $1,350 per month cash-pay before insurance. If your insurance covers branded GLP-1s, services like Ro, Hims, Calibrate, Form Health, and Sesame Care may be cheaper than compounded; if your insurance will not cover them, compounded is usually the cheaper path. Each company’s current offering changes quickly, so verify against their live site if you are choosing between branded and compounded.

How to choose between them

Three questions narrow it down fast:

1. How important is no subscription? Only RxPepsDirect is pay-per-vial with no recurring charge. Every other service on this list is a monthly subscription with either a flat rate or a dose-step escalation. If you want to control spend per fill and avoid auto-renewal, RxPepsDirect is the only answer.
2. How important is a flat monthly bundle? If you want a single number that covers medication, visits, and supplies, Peak Wellness ($149 annual / $165 6-month / $129 month-to-month, flat at every dose) is the cheapest, followed by Mochi Health at $178/month with bundled dietitian support and Eden at $209/month on the 3-month plan across all 50 states.
3. How important is state coverage? Eden Health covers all 50 states. Henry Meds covers 41. RxPepsDirect covers 33. Mochi covers about 10. ShedRx, GobyMeds, and Peak Wellness do not publish their state lists; eligibility is confirmed at intake.

Bottom line

For the lowest starter dollar amount and pay-per-vial economics, RxPepsDirect is the cheapest path at $25 per 1.2mg vial plus a one-time $39 visit, billed through Optimal Balance Pharmacy at wholesale, with the full dose ladder published publicly. For a flat monthly bundle that does not escalate as the dose climbs, Peak Wellness at $149/month on the annual plan is the cheapest option. Mochi Health bundles the most programming for $178/month but only serves about 10 states. Eden Health covers all 50 states with a verticalized in-house pharmacy. Henry Meds, ShedRx, and GobyMeds all sell compounded semaglutide as subscriptions that escalate with dose. Branded Wegovy and Ozempic prescribers are a different category entirely and run many times the cash-pay price.

See RxPepsDirect semaglutide pricing or start a $39 visit.