Dihexa
An angiotensin IV analog that activates HGF/MET receptor system, promoting synaptogenesis and neuroplasticity.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.What It Is
Dihexa is a synthetic peptide derived from angiotensin IV. In research, it has shown remarkable ability to enhance cognitive function and promote new neural connections.
How It Works
It activates the HGF/MET receptor system, which drives the formation of new synaptic connections (synaptogenesis). Research suggests it may be millions of times more potent than BDNF at promoting synaptic connectivity.
Who It's For
Those seeking cognitive enhancement, improved memory formation, and neural connectivity. Often used by professionals and students wanting peak mental performance.
Who Should Avoid It
Limited long-term human data. Not for those with active psychosis. Discuss all psychiatric medications with provider.
Protocol & Pricing
OBP Pharmacy Price
From $3.50/cap
You pay pharmacy price. No markup.
Starting Dose
5mg/cap
Form
Capsule (5mg or 25mg)
Dosing Protocol
1 capsule (5mg) daily by mouth. Take in morning to avoid possible sleep disruption.
Beyond Use Date
180 Days from compounding (USP <797>)
Use within this window from the date your vial is compounded. BUD is set per USP <797> sterile compounding standards and printed on every label.
Stacking Guide
Stacks Well With
Related Peptides
Common questions about Dihexa
- What is dihexa and what does it do?
- Dihexa is a small-molecule analog of angiotensin IV that crosses the blood-brain barrier orally and binds the hepatocyte growth factor (HGF) receptor in the brain. Animal studies show dihexa is roughly seven orders of magnitude more potent than BDNF at promoting synaptogenesis (the formation of new synaptic connections). It is used investigationally for cognitive enhancement, neuroprotection in models of cognitive decline, and post-traumatic brain injury recovery.
- Does dihexa work and is it safe?
- Most efficacy data on dihexa comes from animal models (rats and mice) showing improved spatial memory and synaptogenesis. Human clinical trial data is limited. Anecdotal user reports describe improved focus and mental clarity within hours of dosing. Dihexa is generally well-tolerated at low oral doses; common transient effects include mild headache and occasional sleep disruption if dosed late in the day. There is no large-scale long-term human safety data, so use is investigational and supervised by the prescribing provider.
- How is dihexa dosed?
- Common oral protocols range from 8 to 25 mg per day taken with food. The PeptideRx capsule format simplifies dosing; your provider sets the starting dose based on your goals and tolerance. Most protocols run in cycles of 4 to 8 weeks with breaks rather than continuous use. Take in the morning or early afternoon to avoid sleep disruption.
- How do I take dihexa?
- Dihexa is taken orally as a capsule. Swallow with water, with or without food (food slightly reduces absorption rate but does not affect total bioavailability). Avoid taking dihexa with grapefruit juice or strong CYP inhibitors. Your provider provides a protocol sheet with your shipment.
- How is dihexa supplied?
- Dihexa is dispensed by Optimal Balance Pharmacy in capsule form against PeptideRx prescriptions. Each batch is tested for potency and identity; the Certificate of Analysis is published on this product page. Capsules ship at room temperature and do not require refrigeration. The flat $39 medical visit fee applies regardless of how many peptides are in your order.