Semax/Selank Nasal Spray
Semax modulates BDNF and catecholamines for focus; Selank modulates GABA and serotonin for anxiolytic effects.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.Also available: Semax Nasal Spray, Selank Nasal Spray
What It Is
This combination pairs two Russian-developed nootropic peptides: Semax (focus, BDNF, cognitive enhancement) and Selank (anti-anxiety, calm focus, immune modulation).
How It Works
Semax increases BDNF and modulates dopamine/serotonin for enhanced focus and learning. Selank enhances GABA activity for calm focus without sedation. Together: alert but calm.
Who It's For
Those seeking cognitive enhancement with stress reduction. Perfect for high-pressure professionals who need focus without anxiety. Great for studying and creative work.
Who Should Avoid It
Flag if on lithium. Discuss with provider if on psychiatric medications. Avoid with active psychosis.
Protocol & Pricing
OBP Pharmacy Price
$150/spray
You pay pharmacy price. No markup.
Starting Dose
2.5mg/2.5mg
Form
Nasal spray (15mL, 2.5mg/2.5mg per mL)
Dosing Protocol
1 spray in each nostril daily (250mcg per spray).
Beyond Use Date
35 Days from compounding (nasal spray formulation)
Optimal Balance Pharmacy assigns this date and prints it on your vial label. Always follow the label. Once a multi-dose vial is punctured, the in-use date on the label is shorter than the compounding date shown here.
Stacking Guide
Stacks Well With
Do Not Combine With
Russian nootropic + anxiolytic nasal spray
Read the Semax/Selank Nasal Spray protocol guide
Two heptapeptides in one spray. Semax adds focus, Selank adds calm. Russian clinical use. Non-stimulant, non-sedating, 14 to 21 day course.
Related Peptides
How to get Semax/Selank Nasal Spray prescribed online
Semax/Selank Nasal Spray is available by prescription through a licensed telehealth visit and dispensed for human use by a named 503A pharmacy. That is what separates it from research-use-only vials sold without a prescription. There is no subscription and no membership, just a one-time visit fee.
- 1
Complete a $39 medical visit. Answer a short intake about your health history and your goals for Semax/Selank Nasal Spray. The $39 fee is the only charge Rx Peps Direct collects, paid once, not a recurring subscription.
- 2
A licensed provider reviews it. A US-licensed nurse practitioner or physician reviews your intake and, if Semax/Selank Nasal Spray is appropriate for you, writes a patient-specific prescription. The starting dose is typically 2.5mg/2.5mg.
- 3
The pharmacy compounds and ships it. Optimal Balance Pharmacy, a 503A pharmacy in Texas, compounds Semax/Selank Nasal Spray and ships it ready to use in its dispensed form by FedEx overnight. Your fill is Nasal spray (15mL, 2.5mg/2.5mg per mL), and you pay the pharmacy $150/spray at wholesale, with no clinic markup, plus a $15 flat FedEx overnight shipping fee charged by the pharmacy.
Rx Peps Direct prescribes Semax/Selank Nasal Spray in the 29 jurisdictions its medical team is licensed in. Start a $39 visit or browse the full Cognitive & Brain Health range. Comparing services first? See how Rx Peps Direct stacks up against seven other providers in our best telehealth for compounded peptides comparison.
Common questions about Semax/Selank Nasal Spray
- What is the Semax/Selank nasal spray?
- Semax and Selank are short peptides developed in Russia in the 1980s and 1990s. Semax is an ACTH(4-10) analog used clinically in Russia for stroke recovery and cognitive support; Selank is a tuftsin analog used for anxiety and stress modulation. The Rx Peps Direct nasal spray combines both peptides into one delivery, providing cognitive support (Semax) and anxiolytic effect (Selank) without sedation. Neither peptide is FDA-approved in the United States; both are used investigationally under prescription.
- Does Semax/Selank work for cognition and anxiety?
- The Selank half has the stronger human evidence: in a randomized trial of 62 patients with generalized anxiety disorder or neurasthenia, its anti-anxiety effect was similar to the benzodiazepine medazepam, without sedation. Semax research is mostly in animals and in Russian stroke-recovery studies, where it raised BDNF, a protein tied to learning. Western clinical data on both is limited, so use is supervised by the prescribing provider.
- How do I dose the Semax/Selank nasal spray?
- Optimal Balance Pharmacy's direction is 1 spray in each nostril once daily. Each spray delivers 250 mcg of each peptide. Dose in the morning, because Semax can make it harder to sleep if used late in the day. Russian clinical protocols run these peptides in courses of 14 to 21 days followed by a break, and your provider sets the protocol based on your goals.
- Are there side effects or contraindications for Semax/Selank?
- Both peptides are generally well-tolerated. The most common transient effects are mild nasal irritation at the spray site, occasional headache, and rare alertness-related sleep disturbance if dosed late in the day. Avoid Semax/Selank during pregnancy or while nursing. Patients with chronic sinus disease should ask their provider whether the nasal route is appropriate.
- How is the Semax/Selank spray supplied?
- The Semax/Selank nasal spray is compounded by Optimal Balance Pharmacy in a 15 mL metered nasal-spray bottle at 2.5 mg/mL of each peptide, ready to use. Store it as the printed label directs and use it within the 35-day beyond-use date on the label. It is $150 from the pharmacy, plus the flat $39 Rx Peps Direct medical visit fee, which covers up to three peptides on one order. Semax and Selank are also available as separate sprays at $125 each.