Semax/Selank Nasal Spray
Semax modulates BDNF and catecholamines for focus; Selank modulates GABA and serotonin for anxiolytic effects.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.What It Is
This combination pairs two Russian-developed nootropic peptides: Semax (focus, BDNF, cognitive enhancement) and Selank (anti-anxiety, calm focus, immune modulation).
How It Works
Semax increases BDNF and modulates dopamine/serotonin for enhanced focus and learning. Selank enhances GABA activity for calm focus without sedation. Together: alert but calm.
Who It's For
Those seeking cognitive enhancement with stress reduction. Perfect for high-pressure professionals who need focus without anxiety. Great for studying and creative work.
Who Should Avoid It
Flag if on lithium. Discuss with provider if on psychiatric medications. Avoid with active psychosis.
Protocol & Pricing
OBP Pharmacy Price
$150/spray
You pay pharmacy price. No markup.
Starting Dose
2.5mg/2.5mg
Form
Nasal spray (15mL, 2.5mg/2.5mg per mL)
Dosing Protocol
1 spray in each nostril daily (250mcg per spray).
Beyond Use Date
30 Days from compounding (nasal spray formulation)
Use within this window from the date your vial is compounded. BUD is set per USP <797> sterile compounding standards and printed on every label.
Stacking Guide
Stacks Well With
Related Peptides
Common questions about Semax/Selank Nasal Spray
- What is the Semax/Selank nasal spray?
- Semax and Selank are short peptides developed in Russia in the 1980s and 1990s. Semax is an ACTH(4-10) analog used clinically in Russia for stroke recovery and cognitive support; Selank is a tuftsin analog used for anxiety and stress modulation. The PeptideRx nasal spray combines both peptides into one delivery, providing cognitive support (Semax) and anxiolytic effect (Selank) without sedation. Neither peptide is FDA-approved in the United States; both are used investigationally under prescription.
- Does Semax/Selank work for cognition and anxiety?
- Russian clinical literature on Semax shows improvements in attention, memory, and stroke recovery outcomes. Selank has shown anxiolytic effects in clinical studies comparable to benzodiazepines without sedation or dependency. Combined, users report sharper focus and reduced background anxiety within 30 to 60 minutes of dosing. Long-term U.S. clinical trial data is limited, so use is investigational and supervised by the prescribing provider.
- How do I dose the Semax/Selank nasal spray?
- The standard protocol is 2 to 3 sprays per nostril, once or twice daily. The morning dose targets focus and cognitive performance; an afternoon dose can help with stress modulation. Avoid dosing within 4 hours of bedtime if Selank's modest activating effect interferes with sleep. Your provider sets the protocol based on your goals.
- Are there side effects or contraindications for Semax/Selank?
- Both peptides are generally well-tolerated. The most common transient effects are mild nasal irritation at the spray site, occasional headache, and rare alertness-related sleep disturbance if dosed late in the day. Avoid Semax/Selank during pregnancy or while nursing. Patients with chronic sinus disease should ask their provider whether the nasal route is appropriate.
- How is the Semax/Selank spray supplied?
- The Semax/Selank nasal spray is compounded by Optimal Balance Pharmacy in a metered nasal-spray bottle and ships pre-reconstituted, ready to use. Store at room temperature or refrigerated per the printed label. The Certificate of Analysis for each batch is published on this product page. The flat $39 PeptideRx medical visit fee applies regardless of how many peptides are in your order.