Semax/Selank Nasal Spray

Common questions about Semax/Selank Nasal Spray

What is the Semax/Selank nasal spray?

Semax and Selank are short peptides developed in Russia in the 1980s and 1990s. Semax is an ACTH(4-10) analog used clinically in Russia for stroke recovery and cognitive support; Selank is a tuftsin analog used for anxiety and stress modulation. The Rx Peps Direct nasal spray combines both peptides into one delivery, providing cognitive support (Semax) and anxiolytic effect (Selank) without sedation. Neither peptide is FDA-approved in the United States; both are used investigationally under prescription.

Does Semax/Selank work for cognition and anxiety?

The Selank half has the stronger human evidence: in a randomized trial of 62 patients with generalized anxiety disorder or neurasthenia, its anti-anxiety effect was similar to the benzodiazepine medazepam, without sedation. Semax research is mostly in animals and in Russian stroke-recovery studies, where it raised BDNF, a protein tied to learning. Western clinical data on both is limited, so use is supervised by the prescribing provider.

How do I dose the Semax/Selank nasal spray?

The pharmacy's direction is 1 spray in each nostril once daily. Each spray delivers 250 mcg of each peptide. Dose in the morning, because Semax can make it harder to sleep if used late in the day. Russian clinical protocols run these peptides in courses of 14 to 21 days followed by a break, and your provider sets the protocol based on your goals.

Are there side effects or contraindications for Semax/Selank?

Both peptides are generally well-tolerated. The most common transient effects are mild nasal irritation at the spray site, occasional headache, and rare alertness-related sleep disturbance if dosed late in the day. Avoid Semax/Selank during pregnancy or while nursing. Patients with chronic sinus disease should ask their provider whether the nasal route is appropriate.

How is the Semax/Selank spray supplied?

The Semax/Selank nasal spray is compounded by a licensed U.S. 503A compounding pharmacy in a 15 mL metered nasal-spray bottle at 2.5 mg/mL of each peptide, ready to use. Store it as the printed label directs and use it within the 30-day beyond-use date on the label. It is $150 from the pharmacy, plus the flat $39 Rx Peps Direct medical review, which covers up to three peptides on one order. Semax and Selank are also available as separate sprays at $125 each.