Semax Nasal Spray
Semax is a synthetic analog of the ACTH(4-7) fragment that modulates BDNF and catecholamine signaling.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed September 23, 2026.Also available: Semax/Selank Nasal Spray, Selank Nasal Spray
What It Is
Semax is a heptapeptide developed in Russia from a fragment of adrenocorticotropic hormone (ACTH 4-7) with a Pro-Gly-Pro tail that slows its breakdown. This spray contains Semax alone; the Semax/Selank spray pairs it with Selank.
How It Works
Semax is studied for raising BDNF expression and modulating dopamine and serotonin signaling, which is the basis for its use for focus and learning. Intranasal delivery reaches the central nervous system without an injection.
Who It's For
Patients who want Semax's focus and cognitive support on its own, without Selank's anxiolytic component.
Who Should Avoid It
Discuss with provider if on psychiatric medications. Avoid with active psychosis or pregnancy.
Protocol & Pricing
OBP Pharmacy Price
$125/15ml
You pay pharmacy price. No markup.
Starting Dose
250mcg/spray
Form
Nasal spray (15mL, 2.5mg/mL, 250mcg per spray)
Dosing Protocol
1 spray in each nostril once daily (250mcg per spray), or as directed by your provider.
Beyond Use Date
35 Days from compounding (nasal spray formulation)
Optimal Balance Pharmacy assigns this date and prints it on your vial label. Always follow the label. Once a multi-dose vial is punctured, the in-use date on the label is shorter than the compounding date shown here.
Stacking Guide
Stacks Well With
Do Not Combine With
Russian nootropic + anxiolytic nasal spray
Read the Semax Nasal Spray protocol guide
Two heptapeptides in one spray. Semax adds focus, Selank adds calm. Russian clinical use. Non-stimulant, non-sedating, 14 to 21 day course.
Related Peptides
How to get Semax Nasal Spray prescribed online
Semax Nasal Spray is available by prescription through a licensed telehealth visit and dispensed for human use by a named 503A pharmacy. That is what separates it from research-use-only vials sold without a prescription. There is no subscription and no membership, just a one-time visit fee.
- 1
Complete a $39 medical visit. Answer a short intake about your health history and your goals for Semax Nasal Spray. The $39 fee is the only charge RxPepsDirect collects, paid once, not a recurring subscription.
- 2
A licensed provider reviews it. A US-licensed nurse practitioner or physician reviews your intake and, if Semax Nasal Spray is appropriate for you, writes a patient-specific prescription. The starting dose is typically 250mcg/spray.
- 3
The pharmacy compounds and ships it. Optimal Balance Pharmacy, a 503A pharmacy in Texas, compounds Semax Nasal Spray and ships it ready to use in its dispensed form by FedEx overnight. Your fill is Nasal spray (15mL, 2.5mg/mL, 250mcg per spray), and you pay the pharmacy $125/15ml at wholesale, with no clinic markup, plus a $15 flat FedEx overnight shipping fee charged by the pharmacy.
RxPepsDirect prescribes Semax Nasal Spray in the 29 jurisdictions its medical team is licensed in. Start a $39 visit or browse the full Cognitive & Brain Health range. Comparing services first? See how RxPepsDirect stacks up against seven other providers in our best telehealth for compounded peptides comparison.
Common questions about Semax Nasal Spray
- What is the difference between Semax and Selank?
- Both are short peptides developed in Russia and given as a nasal spray, but they are used for different goals. Semax is derived from a fragment of ACTH and is used for focus and cognitive support. Selank is derived from tuftsin and is used for anxiety without sedation. RxPepsDirect prescribes each on its own at $125 per 15 mL spray, or both together in the Semax/Selank spray at $150. Use one format, not a single spray and the combo together.
- What is the Semax dosage?
- The pharmacy's direction is 1 spray in each nostril once daily. Each spray delivers 250 mcg, so that is 500 mcg a day. Russian clinical protocols run Semax in courses of 14 to 21 days followed by a break, and your provider sets the course length.
- What are the side effects of Semax?
- Semax is generally well tolerated. The most common effects are mild nasal irritation at the spray site, occasional headache, and trouble sleeping if it is dosed late in the day. Avoid it during pregnancy or while nursing, and tell your provider about any psychiatric medications.
- Is Semax FDA approved?
- No. Semax is not FDA-approved in the United States. It is compounded by Optimal Balance Pharmacy, a 503A pharmacy, and dispensed only with a prescription from a licensed provider.
- How long does a bottle of Semax last?
- The 15 mL bottle holds far more than a month of sprays, but the pharmacy assigns it a 35-day beyond-use date, so plan on one bottle about every five weeks and discard any left after the date on the label.