← Cognitive & Brain Health

DSIP

Modulates sleep architecture by promoting delta wave (deep sleep) activity and regulating circadian rhythms.

Dr. Jonathan Snipes, MDMedically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
Learn the Science ↓
DSIP dispensed by a licensed U.S. 503A compounding pharmacy

Verify us before you order

Deep SleepNo DependencyCircadian SupportRecovery

What It Is

DSIP (Delta Sleep Inducing Peptide) is a naturally-occurring neuropeptide that promotes deep, restorative sleep. The phase where most recovery and memory consolidation occurs.

How It Works

It modulates sleep architecture to increase time spent in delta (deep) sleep, regulate cortisol release, and normalize circadian rhythms without the dependency risks of sleep medications.

Who It's For

Those with poor sleep quality, difficulty achieving deep sleep, or disrupted circadian rhythms. Shift workers and high-stress professionals.

Who Should Avoid It

Generally well-tolerated. Discuss with provider if on sleep medications.

Ready to add DSIP?

A licensed provider reviews every order.

Protocol & Pricing

Pharmacy Price

$80

2mg/mL, 5mL vial (10mg total)

You pay pharmacy price. No markup.

Starting Dose

10 units (0.2mg) nightly

Form

Injectable vial, 5mL

Your pharmacy label will read

DSIP

2 MG/ML (5 ML)

The label shows strength per mL, not the total in the vial.

What that means

  • 2mg/mL means 2mg in every mL.
  • The vial holds 5mL, so 2mg/mL × 5mL = 10mg in the vial.

Dosing Protocol

10 units subcutaneous injection at bedtime for the first 14 days, then 15 units nightly. 10 units = 0.1mL × 2mg/mL = 0.2mg per injection; 15 units = 0.3mg. 4 to 12 weeks common, may cycle or continue long term.

Beyond Use Date

90 Days from compounding (USP <797>)

A licensed U.S. 503A compounding pharmacy assigns this date and prints it on your vial label. Always follow the label.

Ready to add DSIP?

A licensed provider reviews every order.

Why this dose, and what the evidence shows

From our medical director's protocol for DSIP. Where the evidence is thin, it says so.

Why this dose

The protocol starts at 0.2 mg before bedtime. Depending on response and morning grogginess, the dose is adjusted during treatment.

DSIP has a short presence in circulation, which is one reason clinical protocols generally place dosing close to bedtime.

The dosing schedule used here comes from clinical practice rather than a modern dose-ranging study.

What the evidence shows

DSIP has been studied in humans, including small placebo-controlled insomnia studies conducted almost entirely from 1981 to 1987.

Results were mixed. Some studies reported improvements in sleep measures, while others found limited differences compared with placebo.

The human studies were small, short, and generally used intravenous DSIP. No large modern trial has established an optimal dose or long-term treatment schedule.

The subcutaneous protocol used here therefore draws from the early research, DSIP pharmacology, and clinical experience rather than a validated insomnia treatment regimen.

Each order also carries the $39 prescriber review. Pharmacy prices are the pharmacy's own; we add nothing to them.

Ready to add DSIP?

A licensed provider reviews every order.

Stacking Guide

Stacks Well With

Semax/Selank Nasal SprayCJC-1295/Ipamorelin

Ready to add DSIP?

A licensed provider reviews every order.

Delta sleep-inducing peptide

Read the DSIP protocol guide

Not a sedative. Most clinical data is 1981 to 1985 IV studies. Slow-wave sleep architecture modulator. 40 to 50 percent non-responder rate.

Read guide

Related Peptides

Semax/Selank Nasal Spray

Russian-developed nootropic combo. Semax for focus and Selank for anxiolytic calm.

$150/spray

CJC-1295/Ipamorelin

The gold standard growth hormone secretagogue stack for lean muscle and recovery.

$100 · 5mL vial of 2 peptides

Independently tested

DSIP certificate of analysis

All 2 DSIP samples tested for sterility and endotoxin passed both. Latest sample received by the lab Oct 9, 2026.

Every DSIP batch dispensed by a licensed U.S. 503A compounding pharmacy is independently tested by Eagle Analytical Services (FDA-registered, A2LA ISO 17025 accredited). Sterility testing checks that nothing grows in the sample; the USP <85> endotoxin test checks for bacterial toxins that can cause fever. Below is the lab's own report for each of the 2 most recent lots.

Lot LG342011170, received Oct 9, 2026

Sterility
PassScanRDI Sterility Test. Started Oct 9, 2026, completed Oct 14, 2026. Method suitability ETX-251231-0177
Bacterial endotoxin
PassUSP <85>. Measured <2 EU/mL, limit 1400 EU/mL. Started Oct 13, 2026, completed Oct 13, 2026
Sample, as printed
DISP 2 MG/ML (5ML)
Lot #
LG342011170
Storage
Refrigerated
Received by lab
Oct 9, 2026
Laboratory
Eagle Analytical Services Inc., Houston, TX
Submission #
ETX-261009-0263
Signed
Alison Eng, Quality Control Manager
Scan of Eagle Analytical report ETX-261009-0263 for lot LG342011170. Opens the original PDF.
Eagle Analytical report ETX-261009-0263. Open the original PDF (opens in a new tab)

Eagle Analytical Services is an independent FDA-registered laboratory, A2LA accredited to ISO 17025, based in Houston, Texas. They have no commercial relationship with Rx Peps Direct. Rx Peps Direct prescribes; the pharmacy compounds and dispenses; Eagle tests every batch. Three separate companies. Results apply only to the tested sample as received. Browse our full quality program on the quality page.

Ready to add DSIP?

A licensed provider reviews every order.

How to get DSIP prescribed online

DSIP is available by prescription after an online medical review and dispensed for human use by a licensed 503A pharmacy. That is what separates it from research-use-only vials sold without a prescription. There is no membership, just a medical review fee per order, and automatic refills are optional.

  1. 1

    Complete a $39 medical review. Answer a short intake about your health history and your goals for DSIP. The $39 fee is the only charge Rx Peps Direct collects, paid once, not a recurring subscription.

  2. 2

    A licensed provider reviews it. A US-licensed clinician reviews your intake and, if DSIP is appropriate for you, writes a patient-specific prescription. The starting dose is typically 10 units (0.2mg) nightly.

  3. 3

    The pharmacy compounds and ships it. A licensed 503A compounding pharmacy in Texas compounds DSIP and ships it pre-reconstituted by FedEx overnight in a reusable cooled case. Your fill is a 5mL injectable vial at 2mg/mL (10mg total), labeled "DSIP 2 MG/ML (5 ML)", and you pay the pharmacy $80 per vial at wholesale, with no clinic markup, plus a $15 flat FedEx overnight shipping fee charged by the pharmacy.

Rx Peps Direct prescribes DSIP in the 28 states plus Washington, DC where its medical team is licensed. Start your $39 medical review or browse the full Cognitive & Brain Health range. Comparing services first? See how Rx Peps Direct stacks up against seven other providers in our best telehealth for compounded peptides comparison.

Ready to add DSIP?

A licensed provider reviews every order.

Common questions about DSIP

What is DSIP (delta sleep-inducing peptide)?
DSIP is a 9-amino acid neuropeptide first isolated from rabbit cerebral venous blood in the 1970s. It is associated with delta-wave (slow-wave) sleep regulation, hypothalamic-pituitary-axis modulation, and stress response normalization. DSIP is studied for primary insomnia, narcolepsy support, opioid and alcohol withdrawal, and chronic pain protocols.
Does DSIP help with sleep, and is it safe?
Small clinical studies and case reports suggest DSIP can shorten sleep onset and improve sleep architecture in patients with chronic insomnia, particularly those with elevated stress markers. The peptide does not produce next-day sedation the way prescription hypnotics often do. Safety data over short-term use is reassuring; long-term data is limited. Most reported side effects are mild (occasional dose-day fatigue, mild headache).
How is DSIP dosed?
The Rx Peps Direct protocol is 10 units (0.2 mg) injected subcutaneously at bedtime for the first 14 days, then 15 units (0.3 mg) nightly. A licensed U.S. 503A compounding pharmacy compounds DSIP in a 10 mg vial at 2 mg/mL against Rx Peps Direct prescriptions, so 10 units on a U-100 insulin syringe is 0.1 mL and 15 units is 0.15 mL. Your provider sets the protocol based on your sleep history.
When should I take DSIP?
Take DSIP 30 to 60 minutes before your intended sleep time. Do not take DSIP if you need to drive or operate machinery within 8 hours. Pair with consistent sleep hygiene (cool bedroom, no screens 30 minutes pre-bed) for best effect. If you wake repeatedly through the night, message your provider to discuss whether the dose or timing needs adjustment.
How is DSIP compounded and shipped?
DSIP is compounded by a licensed U.S. 503A compounding pharmacy under a patient-specific prescription. Every batch is tested by Eagle Analytical Services for sterility (ScanRDI or Celsis) and bacterial endotoxin (USP <85>); the Certificate of Analysis is published on this product page. The vial ships pre-reconstituted and ready to inject in cold-chain packaging with sterile insulin syringes and alcohol swabs included.

Ready to add DSIP?

A licensed provider reviews every order.