Larazotide
A synthetic peptide that regulates intestinal tight junctions, tightening the gut barrier and reducing the increased permeability implicated in celiac disease, IBS, and inflammatory gut conditions.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
What It Is
Larazotide acetate is an oral peptide that acts locally in the gut lumen. It is minimally absorbed and does not enter circulation in meaningful amounts, which is why it is taken before meals: it needs to be in place when food and antigens like gluten arrive.
How It Works
It tightens the junctions between intestinal cells, reducing the leaky-gut permeability that lets antigens through. Because it works in the lumen rather than the bloodstream, timing it ahead of a meal is what makes it effective.
Who It's For
Adults with barrier-related gut symptoms who want a before-meal adjunct. In celiac disease it is an adjunct for residual symptoms despite a gluten-free diet, not a replacement for the diet.
Who Should Avoid It
Not a substitute for a gluten-free diet in celiac disease. Most common effects are mild GI symptoms such as gas, nausea, and headache. Human efficacy data for non-celiac uses is thin; frame expectations accordingly and discuss with your provider.
Protocol & Pricing
OBP Pharmacy Price
$1.80/cap
You pay pharmacy price. No markup.
Starting Dose
One capsule (250 mcg) before meals, up to 3x daily
Form
Oral capsule (250mcg or 500mcg)
Dosing Protocol
Take one capsule by mouth about 15 minutes before a meal, up to three times daily per provider. Minimally absorbed; acts locally in the gut lumen.
Beyond Use Date
180 Days from compounding (USP <795>)
Optimal Balance Pharmacy assigns this date and prints it on your vial label. Always follow the label. Once a multi-dose vial is punctured, the in-use date on the label is shorter than the compounding date shown here.
Stacking Guide
Stacks Well With
Zonulin receptor antagonist (gut permeability)
Read the Larazotide protocol guide
An oral octapeptide that blocks the zonulin receptor to keep intestinal tight junctions closed. More human trial data than most compounded peptides: Phase 2 showed benefit during gluten challenge; Phase 2b primary endpoint narrowly missed but secondary endpoints were significant. Evidence is celiac-specific.
Related Peptides
How to get Larazotide prescribed online
Larazotide is available by prescription through a licensed telehealth visit and dispensed for human use by a named 503A pharmacy. That is what separates it from research-use-only vials sold without a prescription. There is no subscription and no membership, just a one-time visit fee.
- 1
Complete a $39 medical visit. Answer a short intake about your health history and your goals for Larazotide. The $39 fee is the only charge RxPepsDirect collects, paid once, not a recurring subscription.
- 2
A licensed provider reviews it. A US-licensed nurse practitioner or physician reviews your intake and, if Larazotide is appropriate for you, writes a patient-specific prescription. The starting dose is typically One capsule (250 mcg) before meals, up to 3x daily.
- 3
The pharmacy compounds and ships it. Optimal Balance Pharmacy, a 503A pharmacy in Texas, compounds Larazotide and ships it ready to use in its dispensed form by FedEx overnight. Your fill is Oral capsule (250mcg or 500mcg), and you pay the pharmacy $1.80/cap at wholesale, with no clinic markup, plus a $15 flat FedEx overnight shipping fee charged by the pharmacy.
RxPepsDirect prescribes Larazotide in the 29 jurisdictions its medical team is licensed in. Start a $39 visit or browse the full Recovery & Repair range. Comparing services first? See how RxPepsDirect stacks up against seven other providers in our best telehealth for compounded peptides comparison.
Common questions about Larazotide
- What is Larazotide?
- Larazotide acetate is an oral peptide that acts locally in the gut lumen. It is minimally absorbed and does not enter circulation in meaningful amounts, which is why it is taken before meals: it needs to be in place when food and antigens like gluten arrive.
- How does Larazotide work?
- It tightens the junctions between intestinal cells, reducing the leaky-gut permeability that lets antigens through. Because it works in the lumen rather than the bloodstream, timing it ahead of a meal is what makes it effective.
- Who is Larazotide for?
- Adults with barrier-related gut symptoms who want a before-meal adjunct. In celiac disease it is an adjunct for residual symptoms despite a gluten-free diet, not a replacement for the diet.
- How much does Larazotide cost?
- Larazotide costs $1.80/cap from Optimal Balance Pharmacy at wholesale, with a flat $39 medical visit fee from RxPepsDirect. The form is Oral capsule (250mcg or 500mcg).
- What is the Beyond Use Date for Larazotide?
- Optimal Balance Pharmacy assigns the Beyond Use Date for Larazotide and prints it on the vial label. The listed figure is 180 Days from compounding (USP <795>). Always follow the date on your own label, and note that once a multi-dose vial is punctured, the in-use date on the label is shorter than the compounding BUD.