Larazotide 500mcg
A synthetic peptide that regulates intestinal tight junctions, tightening the gut barrier and reducing the increased permeability implicated in celiac disease, IBS, and inflammatory gut conditions.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
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Your prescriber
Kim Callender, NP, FNP-BC
Lead prescriber. Medical director: Jonathan Snipes, MD.
Larazotide 500mcg lab report
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What It Is
The same larazotide acetate capsule as the 250mcg version, compounded at 500mcg per capsule. It acts locally in the gut lumen and is minimally absorbed, so it is taken before meals.
How It Works
It tightens the junctions between intestinal cells, reducing the leaky-gut permeability that lets antigens through. The higher strength delivers more peptide per before-meal dose without adding capsules.
Who It's For
Patients already on 250mcg whose provider has recommended the higher strength. New patients usually start at 250mcg.
Who Should Avoid It
Not a substitute for a gluten-free diet in celiac disease. Most common effects are mild GI symptoms such as gas, nausea, and headache. Human efficacy data for non-celiac uses is thin; frame expectations accordingly and discuss with your provider.
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Protocol & Pricing
Pharmacy Price
$3.50/cap
You pay pharmacy price. No markup.
Starting Dose
One capsule (500 mcg) before meals, up to 3x daily
Form
Oral capsule (500mcg)
Dosing Protocol
Take one capsule by mouth about 15 minutes before a meal, up to three times daily per provider. Minimally absorbed; acts locally in the gut lumen.
Beyond Use Date
180 Days from compounding (USP <795>)
A licensed U.S. 503A compounding pharmacy assigns this date and prints it on your vial label. Always follow the label.
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Stacking Guide
Stacks Well With
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Zonulin receptor antagonist (gut permeability)
Read the Larazotide 500mcg protocol guide
An oral octapeptide that blocks the zonulin receptor to keep intestinal tight junctions closed. More human trial data than most compounded peptides: Phase 2 showed benefit during gluten challenge; Phase 2b primary endpoint narrowly missed but secondary endpoints were significant. Evidence is celiac-specific.
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Oral KPV on its own. The alpha-MSH tripeptide in a 500mcg capsule, with no BPC-157 or TB-500 alongside it.
$2.25/capReady to add Larazotide 500mcg?
A licensed provider reviews every order.
How to get Larazotide 500mcg prescribed online
Larazotide 500mcg is available by prescription after an online medical review and dispensed for human use by a licensed 503A pharmacy. That is what separates it from research-use-only vials sold without a prescription. There is no membership, just a medical review fee per order, and automatic refills are optional.
- 1
Complete a $39 medical review. Answer a short intake about your health history and your goals for Larazotide 500mcg. The $39 fee is the only charge Rx Peps Direct collects, paid once, not a recurring subscription.
- 2
A licensed provider reviews it. A US-licensed clinician reviews your intake and, if Larazotide 500mcg is appropriate for you, writes a patient-specific prescription. The starting dose is typically One capsule (500 mcg) before meals, up to 3x daily.
- 3
The pharmacy compounds and ships it. A licensed 503A compounding pharmacy in Texas compounds Larazotide 500mcg and ships it ready to use in its dispensed form by FedEx overnight. Your fill is Oral capsule (500mcg), and you pay the pharmacy $3.50/cap at wholesale, with no clinic markup, plus a $15 flat FedEx overnight shipping fee charged by the pharmacy.
Rx Peps Direct prescribes Larazotide 500mcg in the 28 states plus Washington, DC where its medical team is licensed. Start your $39 medical review or browse the full Recovery & Repair range. Comparing services first? See how Rx Peps Direct stacks up against seven other providers in our best telehealth for compounded peptides comparison.
Ready to add Larazotide 500mcg?
A licensed provider reviews every order.
Common questions about Larazotide 500mcg
- What is Larazotide 500mcg?
- The same larazotide acetate capsule as the 250mcg version, compounded at 500mcg per capsule. It acts locally in the gut lumen and is minimally absorbed, so it is taken before meals.
- How does Larazotide 500mcg work?
- It tightens the junctions between intestinal cells, reducing the leaky-gut permeability that lets antigens through. The higher strength delivers more peptide per before-meal dose without adding capsules.
- Who is Larazotide 500mcg for?
- Patients already on 250mcg whose provider has recommended the higher strength. New patients usually start at 250mcg.
- How much does Larazotide 500mcg cost?
- Larazotide 500mcg costs $3.50/cap from a licensed U.S. 503A compounding pharmacy at wholesale, with a flat $39 medical review from Rx Peps Direct. The form is Oral capsule (500mcg).
- What is the Beyond Use Date for Larazotide 500mcg?
- A licensed U.S. 503A compounding pharmacy assigns the Beyond Use Date for Larazotide 500mcg and prints it on the vial label. The listed figure is 180 Days from compounding (USP <795>). Always follow the date on your own label.
Ready to add Larazotide 500mcg?
A licensed provider reviews every order.