Kisspeptin
Activates GnRH neurons to stimulate the HPG axis, naturally enhancing reproductive hormones and sexual desire.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
What It Is
Kisspeptin is a naturally-occurring hormone that triggers the release of GnRH (gonadotropin-releasing hormone). It's the 'master switch' of the reproductive system.
How It Works
It activates GnRH neurons in the hypothalamus, which cascade into increased LH and FSH release, naturally boosting testosterone/estrogen and sexual desire.
Who It's For
Those seeking a natural hormonal approach to sexual desire. Also being studied for fertility support. Works well paired with PT-141.
Who Should Avoid It
Discuss with provider if on hormone therapy. Monitor hormone levels.
Protocol & Pricing
OBP Pharmacy Price
$80/5mg
You pay pharmacy price. No markup.
Starting Dose
20 units (0.2mg)
Form
Injectable vial (5mL, 1mg/mL, 5mg total)
Dosing Protocol
20 units subcutaneous injection daily. 20 units = 0.2mL × 1mg/mL = 0.2mg per injection. 8 to 12 weeks duration, may be cycled or extended.
Beyond Use Date
90 Days from compounding (USP <797>)
Optimal Balance Pharmacy assigns this date and prints it on your vial label. Always follow the label. Once a multi-dose vial is punctured, the in-use date on the label is shorter than the compounding date shown here.
Stacking Guide
Stacks Well With
KISS1 / GPR54 reproductive desire peptide protocol
Read the Kisspeptin protocol guide
The upstream switch of the reproductive axis. Unusually for a libido peptide, it has real human data: placebo-controlled brain-imaging RCTs in men and women with low desire. Honest about short-infusion design, the pregnancy contraindication, and WADA status.
Related Peptides
Independently tested
Kisspeptin lab test reports
Every Kisspeptin batch dispensed by Optimal Balance Pharmacy is independently tested by Eagle Analytical Services (FDA-registered, A2LA ISO 17025 accredited) for sterility (ScanRDI or Celsis) and bacterial endotoxin (USP <85>). The most recent report:
| Submission | Lot | Sample | Sterility | Endotoxin | |
|---|---|---|---|---|---|
| ETX-260803-0311 | LG342009663 | KISSPEPTIN 1MG/ML 5ML | Pass | Pass <2 EU/mL / 400 EU/mL | Download |
Eagle Analytical Services is an independent FDA-registered laboratory, A2LA accredited to ISO 17025, based in Houston, Texas. They have no commercial relationship with RxPepsDirect. RxPepsDirect prescribes; Optimal Balance Pharmacy compounds and dispenses; Eagle tests every batch. Three separate companies. Browse our full quality program on the quality page.
How to get Kisspeptin prescribed online
Kisspeptin is available by prescription through a licensed telehealth visit and dispensed for human use by a named 503A pharmacy. That is what separates it from research-use-only vials sold without a prescription. There is no subscription and no membership, just a one-time visit fee.
- 1
Complete a $39 medical visit. Answer a short intake about your health history and your goals for Kisspeptin. The $39 fee is the only charge RxPepsDirect collects, paid once, not a recurring subscription.
- 2
A licensed provider reviews it. A US-licensed nurse practitioner or physician reviews your intake and, if Kisspeptin is appropriate for you, writes a patient-specific prescription. The starting dose is typically 20 units (0.2mg).
- 3
The pharmacy compounds and ships it. Optimal Balance Pharmacy, a 503A pharmacy in Texas, compounds Kisspeptin and ships it pre-reconstituted by FedEx overnight in a reusable cooled case. Your fill is Injectable vial (5mL, 1mg/mL, 5mg total), and you pay the pharmacy $80/5mg at wholesale, with no clinic markup, plus a $15 flat FedEx overnight shipping fee charged by the pharmacy.
RxPepsDirect prescribes Kisspeptin in the 29 jurisdictions its medical team is licensed in. Start a $39 visit or browse the full Sexual Health & Vitality range. Comparing services first? See how RxPepsDirect stacks up against seven other providers in our best telehealth for compounded peptides comparison.
Common questions about Kisspeptin
- What is kisspeptin?
- Kisspeptin is a 54-amino acid peptide (clinically used as the active 10-amino acid fragment KP-10) that triggers gonadotropin-releasing hormone (GnRH) release from the hypothalamus. The GnRH pulse stimulates LH and FSH from the pituitary, which in turn drives testicular and ovarian steroid hormone production. Kisspeptin is studied for hypothalamic amenorrhea, infertility workup, and as a libido and sexual response support peptide in adults with low gonadotropin signaling.
- Does kisspeptin actually increase libido or sexual function?
- Imperial College London studies (published in JCI) showed intravenous kisspeptin increased sexual responsiveness and reward processing in men with low sexual desire. Subcutaneous protocols used by compounding clinics adapt this evidence at lower doses with longer dosing intervals. Effects are typically reported within hours of injection and are not sustained between doses, so kisspeptin is most often dosed before specific events rather than daily.
- How is kisspeptin dosed?
- Common subcutaneous protocols deliver 0.5 to 1 mg per dose 30 to 60 minutes before a target window. Optimal Balance Pharmacy compounds kisspeptin against RxPepsDirect prescriptions; your provider sets the dose based on intent. Do not stack kisspeptin with TRT or anabolic steroids without provider review, because the gonadotropin axis effects can interact in complex ways.
- Where do I inject kisspeptin?
- Subcutaneous injection into the abdomen, upper outer thigh, or back of the upper arm using a 31-gauge, 5/16-inch (8 mm) needle on a U-100 insulin syringe. Sterile syringes are included with every RxPepsDirect shipment. Rotate sites between injections.
- How is kisspeptin supplied?
- Kisspeptin is compounded by Optimal Balance Pharmacy under a 503A patient-specific prescription. The vial ships pre-reconstituted and ready to inject. Every batch is tested by Eagle Analytical Services for sterility (ScanRDI or Celsis) and bacterial endotoxin (USP <85>); the Certificate of Analysis is published on this product page. The flat $39 RxPepsDirect medical visit fee applies regardless of how many peptides are in your order.