← Sexual Health & Vitality

Kisspeptin

Activates GnRH neurons to stimulate the HPG axis, naturally enhancing reproductive hormones and sexual desire.

Dr. Jonathan Snipes, MDMedically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
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Kisspeptin dispensed by a licensed U.S. 503A compounding pharmacy

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Natural HormonalReproductive AxisDesire EnhancementFertility Support

What It Is

Kisspeptin is a naturally-occurring hormone that triggers the release of GnRH (gonadotropin-releasing hormone). It's the 'master switch' of the reproductive system.

How It Works

It activates GnRH neurons in the hypothalamus, which cascade into increased LH and FSH release, naturally boosting testosterone/estrogen and sexual desire.

Who It's For

Those seeking a natural hormonal approach to sexual desire. Also being studied for fertility support. Works well paired with PT-141.

Who Should Avoid It

Discuss with provider if on hormone therapy. Monitor hormone levels.

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A licensed provider reviews every order.

Protocol & Pricing

Pharmacy Price

$80

1mg/mL, 5mL vial (5mg total)

You pay pharmacy price. No markup.

Starting Dose

10 units (0.1mg)

Form

Injectable vial, 5mL

Your pharmacy label will read

KISSPEPTIN

1 MG/ML (5 ML)

The label shows strength per mL, not the total in the vial.

What that means

  • 1mg/mL means 1mg in every mL.
  • The vial holds 5mL, so 1mg/mL × 5mL = 5mg in the vial.
  • Each 10-unit injection (0.1mL) gives you 0.1mg, about 50 injections per vial.

Dosing Protocol

10 units subcutaneous injection twice weekly, 3 to 4 days apart. 10 units = 0.1mL × 1mg/mL = 0.1mg per injection. 8 to 12 weeks duration, may be cycled or extended.

Beyond Use Date

90 Days from compounding (USP <797>)

A licensed U.S. 503A compounding pharmacy assigns this date and prints it on your vial label. Always follow the label.

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A licensed provider reviews every order.

Why this dose, and what the evidence shows

From our medical director's protocol for Kisspeptin. Where the evidence is thin, it says so.

Why this dose

Human studies show that kisspeptin-10 stimulates reproductive hormones, including LH and FSH.

Dose-ranging research found a strong hormone response around 1 microgram per kilogram, with a smaller response at a higher tested dose. The 0.1 mg dose used here falls within the range explored in human research.

Kisspeptin-10 leaves the circulation quickly, so each injection acts primarily as a short hormonal stimulus rather than maintaining a constant blood level.

What the evidence shows

Human studies clearly demonstrate that kisspeptin-10 produces a temporary increase in LH and FSH.

The size of the response varies by sex and, in women, by menstrual-cycle phase.

Research has not established a twice-weekly kisspeptin-10 treatment schedule or shown that intermittent injections produce a sustained hormonal or clinical benefit.

Studies examining sexual and emotional responses have generally used kisspeptin-54 rather than kisspeptin-10. Those findings should therefore be viewed separately from this protocol.

Each order also carries the $39 prescriber review. Pharmacy prices are the pharmacy's own; we add nothing to them.

Ready to add Kisspeptin?

A licensed provider reviews every order.

Stacking Guide

Stacks Well With

PT-141 (Bremelanotide)Oxytocin Nasal Spray

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A licensed provider reviews every order.

KISS1 / GPR54 reproductive desire peptide protocol

Read the Kisspeptin protocol guide

The upstream switch of the reproductive axis. Unusually for a libido peptide, it has real human data: placebo-controlled brain-imaging RCTs in men and women with low desire. Honest about short-infusion design, the pregnancy contraindication, and WADA status.

Read guide

Related Peptides

PT-141 (Bremelanotide)

The only FDA-studied peptide for hypoactive sexual desire. Works through central nervous system pathways.

$75 · 2mg/mL, 5mL vial (10mg total)

Oxytocin Nasal Spray

Intranasal oxytocin for rapid bonding effects and social anxiety reduction.

$35/10ml

Independently tested

Kisspeptin certificate of analysis

All 2 Kisspeptin samples tested for sterility and endotoxin passed both. Latest sample received by the lab Oct 1, 2026.

Every Kisspeptin batch dispensed by a licensed U.S. 503A compounding pharmacy is independently tested by Eagle Analytical Services (FDA-registered, A2LA ISO 17025 accredited). Sterility testing checks that nothing grows in the sample; the USP <85> endotoxin test checks for bacterial toxins that can cause fever. Below is the lab's own report for each of the 2 most recent lots.

Lot LG342011016, received Oct 1, 2026

Sterility
PassCelsis Sterility Test. Started Oct 1, 2026, completed Oct 8, 2026. Method suitability ETX-260112-0496
Bacterial endotoxin
PassUSP <85>. Measured <2 EU/mL, limit 1400 EU/mL. Started Oct 3, 2026, completed Oct 4, 2026
Sample, as printed
KISSPETIN 1 MG/ML (5ML)
Lot #
LG342011016
Storage
Refrigerated
Received by lab
Oct 1, 2026
Laboratory
Eagle Analytical Services Inc., Houston, TX
Submission #
ETX-261001-0348
Signed
Alison Eng, Quality Control Manager
Scan of Eagle Analytical report ETX-261001-0348 for lot LG342011016. Opens the original PDF.
Eagle Analytical report ETX-261001-0348. Open the original PDF (opens in a new tab)

Eagle Analytical Services is an independent FDA-registered laboratory, A2LA accredited to ISO 17025, based in Houston, Texas. They have no commercial relationship with Rx Peps Direct. Rx Peps Direct prescribes; the pharmacy compounds and dispenses; Eagle tests every batch. Three separate companies. Results apply only to the tested sample as received. Browse our full quality program on the quality page.

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A licensed provider reviews every order.

How to get Kisspeptin prescribed online

Kisspeptin is available by prescription after an online medical review and dispensed for human use by a licensed 503A pharmacy. That is what separates it from research-use-only vials sold without a prescription. There is no membership, just a medical review fee per order, and automatic refills are optional.

  1. 1

    Complete a $39 medical review. Answer a short intake about your health history and your goals for Kisspeptin. The $39 fee is the only charge Rx Peps Direct collects, paid once, not a recurring subscription.

  2. 2

    A licensed provider reviews it. A US-licensed clinician reviews your intake and, if Kisspeptin is appropriate for you, writes a patient-specific prescription. The starting dose is typically 10 units (0.1mg).

  3. 3

    The pharmacy compounds and ships it. A licensed 503A compounding pharmacy in Texas compounds Kisspeptin and ships it pre-reconstituted by FedEx overnight in a reusable cooled case. Your fill is a 5mL injectable vial at 1mg/mL (5mg total), labeled "KISSPEPTIN 1 MG/ML (5 ML)", and you pay the pharmacy $80 per vial at wholesale, with no clinic markup, plus a $15 flat FedEx overnight shipping fee charged by the pharmacy.

Rx Peps Direct prescribes Kisspeptin in the 28 states plus Washington, DC where its medical team is licensed. Start your $39 medical review or browse the full Sexual Health & Vitality range. Comparing services first? See how Rx Peps Direct stacks up against seven other providers in our best telehealth for compounded peptides comparison.

Ready to add Kisspeptin?

A licensed provider reviews every order.

Common questions about Kisspeptin

What is kisspeptin?
Kisspeptin is a 54-amino acid peptide (clinically used as the active 10-amino acid fragment KP-10) that triggers gonadotropin-releasing hormone (GnRH) release from the hypothalamus. The GnRH pulse stimulates LH and FSH from the pituitary, which in turn drives testicular and ovarian steroid hormone production. Kisspeptin is studied for hypothalamic amenorrhea, infertility workup, and as a libido and sexual response support peptide in adults with low gonadotropin signaling.
Does kisspeptin actually increase libido or sexual function?
Imperial College London studies (published in JCI) showed intravenous kisspeptin increased sexual responsiveness and reward processing in men with low sexual desire. Subcutaneous protocols used by compounding clinics adapt this evidence at lower doses with longer dosing intervals. Effects are typically reported within hours of injection and are not sustained between doses, so kisspeptin is most often dosed before specific events rather than daily.
How is kisspeptin dosed?
The Rx Peps Direct starting dose is 10 units (0.1 mg) on a U-100 insulin syringe, injected subcutaneously twice weekly, 3 to 4 days apart. A licensed U.S. 503A compounding pharmacy compounds kisspeptin at 1 mg/mL against Rx Peps Direct prescriptions, so 10 units is 0.1 mL; your provider confirms or adjusts the dose at review. Do not stack kisspeptin with TRT or anabolic steroids without medical review, because the gonadotropin axis effects can interact in complex ways.
Where do I inject kisspeptin?
Subcutaneous injection into the abdomen, upper outer thigh, or back of the upper arm using a 31-gauge, 5/16-inch (8 mm) needle on a U-100 insulin syringe. Sterile syringes are included with every Rx Peps Direct shipment. Rotate sites between injections.
How is kisspeptin supplied?
Kisspeptin is compounded by a licensed U.S. 503A compounding pharmacy under a patient-specific prescription. The vial ships pre-reconstituted and ready to inject. Every batch is tested by Eagle Analytical Services for sterility (ScanRDI or Celsis) and bacterial endotoxin (USP <85>); the Certificate of Analysis is published on this product page. The flat $39 Rx Peps Direct medical review applies regardless of how many peptides are in your order.

Ready to add Kisspeptin?

A licensed provider reviews every order.