Kisspeptin
Activates GnRH neurons to stimulate the HPG axis, naturally enhancing reproductive hormones and sexual desire.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.What It Is
Kisspeptin is a naturally-occurring hormone that triggers the release of GnRH (gonadotropin-releasing hormone). It's the 'master switch' of the reproductive system.
How It Works
It activates GnRH neurons in the hypothalamus, which cascade into increased LH and FSH release, naturally boosting testosterone/estrogen and sexual desire.
Who It's For
Those seeking a natural hormonal approach to sexual desire. Also being studied for fertility support. Works well paired with PT-141.
Who Should Avoid It
Discuss with provider if on hormone therapy. Monitor hormone levels.
Protocol & Pricing
OBP Pharmacy Price
$80/5mg
You pay pharmacy price. No markup.
Starting Dose
20 units (0.2mg)
Form
Injectable vial (5mL, 1mg/mL, 5mg total)
Dosing Protocol
20 units subcutaneous injection daily. 20 units = 0.2mL × 1mg/mL = 0.2mg per injection. 8–12 weeks duration, may be cycled or extended.
Beyond Use Date
90 Days from compounding (USP <797>)
Use within this window from the date your vial is compounded. BUD is set per USP <797> sterile compounding standards and printed on every label.
Stacking Guide
Stacks Well With
Related Peptides
Common questions about Kisspeptin
- What is kisspeptin?
- Kisspeptin is a 54-amino acid peptide (clinically used as the active 10-amino acid fragment KP-10) that triggers gonadotropin-releasing hormone (GnRH) release from the hypothalamus. The GnRH pulse stimulates LH and FSH from the pituitary, which in turn drives testicular and ovarian steroid hormone production. Kisspeptin is studied for hypothalamic amenorrhea, infertility workup, and as a libido and sexual response support peptide in adults with low gonadotropin signaling.
- Does kisspeptin actually increase libido or sexual function?
- Imperial College London studies (published in JCI) showed intravenous kisspeptin increased sexual responsiveness and reward processing in men with low sexual desire. Subcutaneous protocols used by compounding clinics adapt this evidence at lower doses with longer dosing intervals. Effects are typically reported within hours of injection and are not sustained between doses, so kisspeptin is most often dosed before specific events rather than daily.
- How is kisspeptin dosed?
- Common subcutaneous protocols deliver 0.5 to 1 mg per dose 30 to 60 minutes before a target window. Optimal Balance Pharmacy compounds kisspeptin against PeptideRx prescriptions; your provider sets the dose based on intent. Do not stack kisspeptin with TRT or anabolic steroids without provider review, because the gonadotropin axis effects can interact in complex ways.
- Where do I inject kisspeptin?
- Subcutaneous injection into the abdomen, upper outer thigh, or back of the upper arm using a 31-gauge, 5/16-inch (8 mm) needle on a U-100 insulin syringe. Sterile syringes are included with every PeptideRx shipment. Rotate sites between injections.
- How is kisspeptin supplied?
- Kisspeptin is compounded by Optimal Balance Pharmacy under a 503A patient-specific prescription. The vial ships pre-reconstituted and ready to inject. Every batch is tested by Eagle Analytical Services for sterility (ScanRDI or Celsis) and bacterial endotoxin (USP <85>); the Certificate of Analysis is published on this product page. The flat $39 PeptideRx medical visit fee applies regardless of how many peptides are in your order.