GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%)
Pairs GHK-Cu (collagen and ECM signaling) with low-dose topical estriol (estrogen receptor activation in dermal fibroblasts, supporting collagen density and dermal hydration). Estriol is the weakest natural estrogen and at 0.003% the systemic absorption is intentionally negligible.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
What It Is
A compounded prescription cream combining 3% GHK-Cu and 0.003% estriol. Estriol is used in dermatology to support collagen density and skin hydration in mature or estrogen-deficient skin. The 0.003% concentration is below systemic-absorption thresholds in published topical pharmacokinetic studies.
How It Works
Applied to clean skin in the evening. GHK-Cu drives ECM remodeling; estriol activates estrogen receptors on dermal fibroblasts to support endogenous collagen production. The combination targets the loss of skin density that follows declining estrogen levels.
Who It's For
Post-menopausal patients or patients with documented estrogen-deficient skin changes (thinning, loss of firmness, dryness). Not a systemic hormone replacement therapy; effects are localized to the application site.
Who Should Avoid It
Hard contraindication in pregnancy and breastfeeding. Hormone-sensitive cancer history (ER-positive breast cancer, endometrial cancer) flags for provider review. Known copper allergy.
Protocol & Pricing
OBP Pharmacy Price
$100/30gm
You pay pharmacy price. No markup.
Starting Dose
Pea-sized amount once daily (evening)
Form
Topical cream (30g jar, GHK-Cu 30mg/g, Estriol 0.03mg/g)
Dosing Protocol
Apply a pea-sized amount to face and neck once daily in the evening after cleansing. Avoid eye area. 30g jar covers approximately 90 days of daily use.
Beyond Use Date
180 Days from compounding (USP <797>)
Use within this window from the date your vial is compounded. BUD is set per USP <797> sterile compounding standards and printed on every label.
Stacking Guide
Stacks Well With
Do Not Combine With
Topical copper peptide protocol
Read the GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%) protocol guide
Why prescription compounded GHK-Cu (1 to 3 percent) outperforms The Ordinary, Biossance, and NIOD (0.05 to 0.1 percent). The seven topical SKUs RxPepsDirect prescribes and how to pick between them.
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$50/30gmCommon questions about GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%)
- What is GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%)?
- A compounded prescription cream combining 3% GHK-Cu and 0.003% estriol. Estriol is used in dermatology to support collagen density and skin hydration in mature or estrogen-deficient skin. The 0.003% concentration is below systemic-absorption thresholds in published topical pharmacokinetic studies.
- How does GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%) work?
- Applied to clean skin in the evening. GHK-Cu drives ECM remodeling; estriol activates estrogen receptors on dermal fibroblasts to support endogenous collagen production. The combination targets the loss of skin density that follows declining estrogen levels.
- Who is GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%) for?
- Post-menopausal patients or patients with documented estrogen-deficient skin changes (thinning, loss of firmness, dryness). Not a systemic hormone replacement therapy; effects are localized to the application site.
- How much does GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%) cost?
- GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%) costs $100/30gm from Optimal Balance Pharmacy at wholesale, with a flat $39 medical visit fee from RxPepsDirect. The form is Topical cream (30g jar, GHK-Cu 30mg/g, Estriol 0.03mg/g).
- What is the Beyond Use Date for GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%)?
- 180 Days from compounding (USP <797>) BUDs are assigned per USP <797> sterile compounding standards and printed on every vial label.