GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%)
Pairs GHK-Cu (collagen and ECM signaling) with low-dose topical estriol (estrogen receptor activation in dermal fibroblasts, supporting collagen density and dermal hydration). Estriol is the weakest natural estrogen and at 0.003% the systemic absorption is intentionally negligible.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
What It Is
A compounded prescription cream combining 3% GHK-Cu and 0.003% estriol. Estriol is used in dermatology to support collagen density and skin hydration in mature or estrogen-deficient skin. The 0.003% concentration is below systemic-absorption thresholds in published topical pharmacokinetic studies.
How It Works
Applied to clean skin in the evening. GHK-Cu drives ECM remodeling; estriol activates estrogen receptors on dermal fibroblasts to support endogenous collagen production. The combination targets the loss of skin density that follows declining estrogen levels.
Who It's For
Post-menopausal patients or patients with documented estrogen-deficient skin changes (thinning, loss of firmness, dryness). Not a systemic hormone replacement therapy; effects are localized to the application site.
Who Should Avoid It
Hard contraindication in pregnancy and breastfeeding. Hormone-sensitive cancer history (ER-positive breast cancer, endometrial cancer) flags for provider review. Known copper allergy.
Protocol & Pricing
OBP Pharmacy Price
$100/30gm
You pay pharmacy price. No markup.
Starting Dose
Pea-sized amount once daily (evening)
Form
Topical cream (30g jar, GHK-Cu 30mg/g, Estriol 0.03mg/g)
Dosing Protocol
Apply a pea-sized amount to face and neck once daily in the evening after cleansing. Avoid eye area. 30g jar covers approximately 90 days of daily use.
Beyond Use Date
180 Days from compounding (USP <795>)
Optimal Balance Pharmacy assigns this date and prints it on your vial label. Always follow the label. Once a multi-dose vial is punctured, the in-use date on the label is shorter than the compounding date shown here.
Stacking Guide
Stacks Well With
Do Not Combine With
Topical copper peptide protocol
Read the GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%) protocol guide
Why prescription compounded GHK-Cu (1 to 3 percent) outperforms The Ordinary, Biossance, and NIOD (0.05 to 0.1 percent). The seven topical peptides RxPepsDirect prescribes and how to pick between them.
Related Peptides
GHK-Cu Niacinamide Firm Boost Serum
Lightweight 3% GHK-Cu and 3% niacinamide serum for face and neck. Firming and barrier repair without the SNAP-8 layer.
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Compounded 0.0064% methylene blue and 0.003% estriol cream. Targets mitochondrial dysfunction in aging skin without visible blue staining.
$50/30gmHow to get GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%) prescribed online
GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%) is available by prescription through a licensed telehealth visit and dispensed for human use by a named 503A pharmacy. That is what separates it from research-use-only vials sold without a prescription. There is no subscription and no membership, just a one-time visit fee.
- 1
Complete a $39 medical visit. Answer a short intake about your health history and your goals for GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%). The $39 fee is the only charge RxPepsDirect collects, paid once, not a recurring subscription.
- 2
A licensed provider reviews it. A US-licensed nurse practitioner or physician reviews your intake and, if GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%) is appropriate for you, writes a patient-specific prescription. The starting dose is typically Pea-sized amount once daily (evening).
- 3
The pharmacy compounds and ships it. Optimal Balance Pharmacy, a 503A pharmacy in Texas, compounds GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%) and ships it ready to use in its dispensed form by FedEx overnight. Your fill is Topical cream (30g jar, GHK-Cu 30mg/g, Estriol 0.03mg/g), and you pay the pharmacy $100/30gm at wholesale, with no clinic markup, plus a $15 flat FedEx overnight shipping fee charged by the pharmacy.
RxPepsDirect prescribes GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%) in the 28 states its medical team is licensed in. Start a $39 visit or browse the full Skin & Hair range. Comparing services first? See how RxPepsDirect stacks up against seven other providers in our best telehealth for compounded peptides comparison.
Common questions about GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%)
- What is GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%)?
- A compounded prescription cream combining 3% GHK-Cu and 0.003% estriol. Estriol is used in dermatology to support collagen density and skin hydration in mature or estrogen-deficient skin. The 0.003% concentration is below systemic-absorption thresholds in published topical pharmacokinetic studies.
- How does GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%) work?
- Applied to clean skin in the evening. GHK-Cu drives ECM remodeling; estriol activates estrogen receptors on dermal fibroblasts to support endogenous collagen production. The combination targets the loss of skin density that follows declining estrogen levels.
- Who is GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%) for?
- Post-menopausal patients or patients with documented estrogen-deficient skin changes (thinning, loss of firmness, dryness). Not a systemic hormone replacement therapy; effects are localized to the application site.
- How much does GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%) cost?
- GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%) costs $100/30gm from Optimal Balance Pharmacy at wholesale, with a flat $39 medical visit fee from RxPepsDirect. The form is Topical cream (30g jar, GHK-Cu 30mg/g, Estriol 0.03mg/g).
- What is the Beyond Use Date for GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%)?
- Optimal Balance Pharmacy assigns the Beyond Use Date for GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.003%) and prints it on the vial label. The listed figure is 180 Days from compounding (USP <795>). Always follow the date on your own label, and note that once a multi-dose vial is punctured, the in-use date on the label is shorter than the compounding BUD.