GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.3%)
Pairs GHK-Cu (collagen and ECM signaling) with 0.3% topical estriol (estrogen receptor activation in dermal fibroblasts, supporting collagen density and dermal hydration). Estriol is the weakest of the three natural estrogens, and 0.3% is the estriol concentration used in published topical skin-aging studies.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
What It Is
A compounded prescription cream combining 3% GHK-Cu and 0.3% estriol. Estriol is used in dermatology to support collagen density and skin hydration in mature or estrogen-deficient skin. In a 6-month study of 0.3% estriol cream in 59 women, skin firmness, hydration and wrinkle depth improved and type III collagen increased, with no systemic hormonal side effects measured other than a rise in prolactin (Schmidt et al., Int J Dermatol 1996).
How It Works
Applied to clean skin in the evening. GHK-Cu drives ECM remodeling; estriol activates estrogen receptors on dermal fibroblasts to support endogenous collagen production. The combination targets the loss of skin density that follows declining estrogen levels.
Who It's For
Post-menopausal patients or patients with documented estrogen-deficient skin changes (thinning, loss of firmness, dryness). Not a systemic hormone replacement therapy; it is applied to the face and neck only.
Who Should Avoid It
Hard contraindication in pregnancy and breastfeeding. Hormone-sensitive cancer history (ER-positive breast cancer, endometrial cancer) flags for provider review. Known copper allergy.
Protocol & Pricing
Pharmacy Price
$100/30gm
You pay pharmacy price. No markup.
Starting Dose
Pea-sized amount once daily (evening)
Form
Topical cream (30g jar, GHK-Cu 30mg/g, Estriol 3mg/g)
Dosing Protocol
Apply a pea-sized amount to face and neck once daily in the evening after cleansing. Avoid eye area. 30g jar covers approximately 90 days of daily use.
Beyond Use Date
180 Days from compounding (USP <795>)
A licensed U.S. 503A compounding pharmacy assigns this date and prints it on your vial label. Always follow the label.
Stacking Guide
Stacks Well With
Do Not Combine With
Topical copper peptide protocol
Read the GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.3%) protocol guide
Why prescription compounded GHK-Cu (1 to 3 percent) outperforms The Ordinary, Biossance, and NIOD (0.05 to 0.1 percent). The seven topical peptides Rx Peps Direct prescribes and how to pick between them.
Related Peptides
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Lightweight 3% GHK-Cu and 3% niacinamide serum for face and neck. Firming and barrier repair without the SNAP-8 layer.
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Compounded 0.0064% methylene blue and 0.003% estriol cream. Targets mitochondrial dysfunction in aging skin without visible blue staining.
$50/30gmHow to get GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.3%) prescribed online
GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.3%) is available by prescription through a licensed telehealth visit and dispensed for human use by a licensed 503A pharmacy. That is what separates it from research-use-only vials sold without a prescription. There is no membership, just a medical review fee per order, and automatic refills are optional.
- 1
Complete a $39 medical review. Answer a short intake about your health history and your goals for GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.3%). The $39 fee is the only charge Rx Peps Direct collects, paid once, not a recurring subscription.
- 2
A licensed provider reviews it. A US-licensed clinician reviews your intake and, if GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.3%) is appropriate for you, writes a patient-specific prescription. The starting dose is typically Pea-sized amount once daily (evening).
- 3
The pharmacy compounds and ships it. A licensed 503A compounding pharmacy in Texas compounds GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.3%) and ships it ready to use in its dispensed form by FedEx overnight. Your fill is Topical cream (30g jar, GHK-Cu 30mg/g, Estriol 3mg/g), and you pay the pharmacy $100/30gm at wholesale, with no clinic markup, plus a $15 flat FedEx overnight shipping fee charged by the pharmacy.
Rx Peps Direct prescribes GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.3%) in the 28 states plus Washington, DC where its medical team is licensed. Start a $39 visit or browse the full Skin & Hair range. Comparing services first? See how Rx Peps Direct stacks up against seven other providers in our best telehealth for compounded peptides comparison.
Common questions about GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.3%)
- What is GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.3%)?
- A compounded prescription cream combining 3% GHK-Cu and 0.3% estriol. Estriol is used in dermatology to support collagen density and skin hydration in mature or estrogen-deficient skin. In a 6-month study of 0.3% estriol cream in 59 women, skin firmness, hydration and wrinkle depth improved and type III collagen increased, with no systemic hormonal side effects measured other than a rise in prolactin (Schmidt et al., Int J Dermatol 1996).
- How does GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.3%) work?
- Applied to clean skin in the evening. GHK-Cu drives ECM remodeling; estriol activates estrogen receptors on dermal fibroblasts to support endogenous collagen production. The combination targets the loss of skin density that follows declining estrogen levels.
- Who is GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.3%) for?
- Post-menopausal patients or patients with documented estrogen-deficient skin changes (thinning, loss of firmness, dryness). Not a systemic hormone replacement therapy; it is applied to the face and neck only.
- How much does GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.3%) cost?
- GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.3%) costs $100/30gm from a licensed U.S. 503A compounding pharmacy at wholesale, with a flat $39 medical review from Rx Peps Direct. The form is Topical cream (30g jar, GHK-Cu 30mg/g, Estriol 3mg/g).
- What is the Beyond Use Date for GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.3%)?
- A licensed U.S. 503A compounding pharmacy assigns the Beyond Use Date for GHK-Cu Biocosmetic Cream (GHK-Cu 3% / Estriol 0.3%) and prints it on the vial label. The listed figure is 180 Days from compounding (USP <795>). Always follow the date on your own label.