Methylcobalamin (B12)
Methylcobalamin is the bioactive coenzyme form of vitamin B12, a cofactor in methionine synthase (methylation), red blood cell formation, and neurological function.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
What It Is
An injectable form of vitamin B12 as methylcobalamin, the pre-activated coenzyme the body uses directly without converting from cyanocobalamin. Self-administered intramuscular or subcutaneous.
How It Works
Methylcobalamin donates methyl groups in the methionine and folate cycles, supporting homocysteine metabolism, red blood cell production, and nerve myelination. Injection bypasses gut absorption, useful for patients with low B12 despite oral supplements.
Who It's For
Patients with low B12, fatigue, or malabsorption (including those on GLP-1 therapy), and anyone wanting the active methyl form rather than cyanocobalamin.
Who Should Avoid It
Known cobalt or cobalamin allergy. Use caution with Leber's hereditary optic neuropathy. Generally very well tolerated.
Protocol & Pricing
OBP Pharmacy Price
From $30/10ml
You pay pharmacy price. No markup.
Starting Dose
1mg (0.2mL) once weekly
Form
Injectable vial (10mL or 30mL, 5mg/mL methylcobalamin)
Dosing Protocol
1mg (0.2mL at 5mg/mL) intramuscular or subcutaneous once weekly, or per provider. Two vial sizes: 10mL ($30) and 30mL ($65).
Beyond Use Date
90 Days from compounding (USP <797>)
Use within this window from the date your vial is compounded. BUD is set per USP <797> sterile compounding standards and printed on every label.
Stacking Guide
Stacks Well With
Related Peptides
Lipo-B (Cyanocobalamin/MIC)
A lipotropic injection combining cyanocobalamin (B12) with methionine, inositol, and choline for fat metabolism.
From $30/10mlLipo-C (Cyanocobalamin/MIC/L-Carnitine)
Enhanced lipotropic injection adding L-carnitine to cyanocobalamin and MIC for improved energy and fat transport.
From $35/10mlVitamin B-Complex
Injectable B-complex (B1, B2, B3, B6) for energy metabolism and nervous system support.
$40/30mlCommon questions about Methylcobalamin (B12)
- What is Methylcobalamin (B12)?
- An injectable form of vitamin B12 as methylcobalamin, the pre-activated coenzyme the body uses directly without converting from cyanocobalamin. Self-administered intramuscular or subcutaneous.
- How does Methylcobalamin (B12) work?
- Methylcobalamin donates methyl groups in the methionine and folate cycles, supporting homocysteine metabolism, red blood cell production, and nerve myelination. Injection bypasses gut absorption, useful for patients with low B12 despite oral supplements.
- Who is Methylcobalamin (B12) for?
- Patients with low B12, fatigue, or malabsorption (including those on GLP-1 therapy), and anyone wanting the active methyl form rather than cyanocobalamin.
- How much does Methylcobalamin (B12) cost?
- Methylcobalamin (B12) costs From $30/10ml from Optimal Balance Pharmacy at wholesale, with a flat $39 medical visit fee from RxPepsDirect. The form is Injectable vial (10mL or 30mL, 5mg/mL methylcobalamin).
- What is the Beyond Use Date for Methylcobalamin (B12)?
- 90 Days from compounding (USP <797>) BUDs are assigned per USP <797> sterile compounding standards and printed on every vial label.