Methylene Blue 25mg
Maximum therapeutic dose of mitochondrial electron carrier for advanced protocols.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.What It Is
Maximum dose Methylene Blue for advanced users on intensive protocols with strict provider oversight.
How It Works
Same mechanism at maximum therapeutic dose. Beyond this, methylene blue can become pro-oxidant rather than antioxidant.
Who It's For
Advanced users only. Strict provider supervision required. Must have established tolerance at lower doses.
Who Should Avoid It
Same as all MB. Provider must approve. Regular lab monitoring required.
Protocol & Pricing
OBP Pharmacy Price
$2.50/cap
You pay pharmacy price. No markup.
Starting Dose
25mg/cap
Form
Capsule (25mg)
Dosing Protocol
1 capsule (25mg) daily by mouth in the morning. Strict provider monitoring.
Beyond Use Date
180 Days from compounding (USP <797>)
Use within this window from the date your vial is compounded. BUD is set per USP <797> sterile compounding standards and printed on every label.
Stacking Guide
Stacks Well With
Do Not Combine With
Related Peptides
Common questions about Methylene Blue 25mg
- What is the 25 mg methylene blue capsule used for?
- The 25 mg methylene blue capsule is a high-dose strength reserved for adults who have tolerated 15 mg without issue and whose provider has cleared them for further escalation. At 25 mg per day, methylene blue's MAOI activity becomes clinically meaningful, which dramatically increases the strength of any drug-interaction risk and which the prescribing provider will weigh carefully.
- Is 25 mg too high a dose? Who should not take it?
- 25 mg is the highest standard nootropic dose Optimal Balance Pharmacy compounds and is not appropriate for first-time methylene blue users, patients with cardiovascular conditions, patients on any serotonergic medication, patients with hepatic impairment, or patients with G6PD deficiency. Doses above 50 mg per day enter pharmacological territory used in formal clinical settings (such as treating methemoglobinemia) and require monitored medical supervision rather than at-home dosing.
- How is 25 mg methylene blue dosed?
- Take one capsule per day in the morning with water on an empty stomach. Do not take a second capsule the same day. Some protocols use 25 mg every other day or 5 days on and 2 days off rather than daily continuous dosing. Your provider sets the schedule based on your goals and tolerance.
- What is the most common protocol for 25 mg methylene blue?
- A common protocol is 25 mg taken once daily in the morning, 5 days on and 2 days off, run for 4 to 8 weeks at a time with breaks. The breaks reduce cumulative MAOI exposure and let the patient assess off-protocol baseline. Long-term continuous daily 25 mg dosing is generally not recommended because of the cumulative serotonergic-interaction risk.
- What medications cannot be combined with 25 mg methylene blue?
- Avoid SSRIs (sertraline, fluoxetine, escitalopram), SNRIs (venlafaxine, duloxetine), MAOIs, tricyclic antidepressants, lithium, tramadol, dextromethorphan, St. John's Wort, and any serotonergic medication. At 25 mg, methylene blue's MAOI activity is high enough that the combined-use risk of serotonin syndrome is the strictest of any methylene blue strength. PeptideRx providers screen for these on every intake and auto-deny the prescription if any conflict is flagged.