Ibutamoren (MK-677) 25mg
An oral ghrelin receptor agonist that stimulates sustained GH and IGF-1 elevation.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
What It Is
The same ibutamoren (MK-677) capsule as the 12.5mg version, compounded at 25mg per capsule.
How It Works
By activating the ghrelin receptor, it signals the pituitary to release GH. One 25mg capsule replaces the 12.5mg dose without adding capsules.
Who It's For
Patients already on 12.5mg who tolerate it and whose provider has recommended the higher strength. New patients usually start at 12.5mg.
Who Should Avoid It
May increase appetite significantly. Monitor blood sugar. Not for diabetics without careful management. Avoid with active cancer.
Protocol & Pricing
OBP Pharmacy Price
$2.65/cap
You pay pharmacy price. No markup.
Starting Dose
25mg/day
Form
Capsule (25mg)
Dosing Protocol
1 capsule daily, taken in the evening to align with natural GH peak.
Beyond Use Date
180 Days from compounding (USP <795>)
Optimal Balance Pharmacy assigns this date and prints it on your vial label. Always follow the label. Once a multi-dose vial is punctured, the in-use date on the label is shorter than the compounding date shown here.
Stacking Guide
Stacks Well With
Oral GH secretagogue (MK-677)
Read the Ibutamoren (MK-677) 25mg protocol guide
The only oral GH secretagogue. Real GH and IGF-1 elevation. Real water retention. Real fasting-glucose drift. WADA prohibited. Monitoring is mandatory.
Related Peptides
How to get Ibutamoren (MK-677) 25mg prescribed online
Ibutamoren (MK-677) 25mg is available by prescription through a licensed telehealth visit and dispensed for human use by a named 503A pharmacy. That is what separates it from research-use-only vials sold without a prescription. There is no subscription and no membership, just a one-time visit fee.
- 1
Complete a $39 medical visit. Answer a short intake about your health history and your goals for Ibutamoren (MK-677) 25mg. The $39 fee is the only charge Rx Peps Direct collects, paid once, not a recurring subscription.
- 2
A licensed provider reviews it. A US-licensed nurse practitioner or physician reviews your intake and, if Ibutamoren (MK-677) 25mg is appropriate for you, writes a patient-specific prescription. The starting dose is typically 25mg/day.
- 3
The pharmacy compounds and ships it. Optimal Balance Pharmacy, a 503A pharmacy in Texas, compounds Ibutamoren (MK-677) 25mg and ships it ready to use in its dispensed form by FedEx overnight. Your fill is Capsule (25mg), and you pay the pharmacy $2.65/cap at wholesale, with no clinic markup, plus a $15 flat FedEx overnight shipping fee charged by the pharmacy.
Rx Peps Direct prescribes Ibutamoren (MK-677) 25mg in the 29 jurisdictions its medical team is licensed in. Start a $39 visit or browse the full Muscle Growth & Body Composition range. Comparing services first? See how Rx Peps Direct stacks up against seven other providers in our best telehealth for compounded peptides comparison.
Common questions about Ibutamoren (MK-677) 25mg
- What is ibutamoren (MK-677)?
- Ibutamoren (also known as MK-677) is an orally active small-molecule ghrelin receptor agonist that stimulates pituitary growth hormone release. Despite the molecule often being lumped with peptides, it is not technically a peptide; it is a small-molecule mimetic of the ghrelin receptor's natural ligand. It has been studied for sarcopenia, growth hormone deficiency, and recovery support.
- Is MK-677 a peptide, a SARM, or a steroid?
- None of those. MK-677 is a small-molecule ghrelin receptor agonist (a growth hormone secretagogue). It does not contain a peptide bond, does not bind androgen receptors (so it is not a SARM), and does not contain a steroid backbone. It is regulated as an investigational compound; WADA banned it for elite competitive sport.
- Is MK-677 safe?
- MK-677 has been studied in clinical trials at doses of 25 mg per day for up to 12 months without serious adverse events. Common side effects include increased appetite (the ghrelin-agonist mechanism), mild fluid retention, transient elevations in fasting glucose, and occasional next-day grogginess if dosed too late. Patients with diabetes or pre-diabetes should use MK-677 with provider monitoring of fasting glucose and HbA1c.
- How is MK-677 dosed?
- Common oral protocols deliver 10 to 25 mg once daily. Most patients dose in the evening to align the GH pulse with natural overnight release and to limit daytime appetite increase. Optimal Balance Pharmacy compounds MK-677 in capsule form against Rx Peps Direct prescriptions; your provider sets the dose based on your goals.
- Does MK-677 affect testosterone or natural GH production long-term?
- MK-677 does not directly affect testosterone or the HPG axis the way exogenous testosterone or anabolic steroids do. It works on the ghrelin receptor to stimulate the body's own GH release, so it preserves the negative feedback loop of natural pulsatile GH. Long-term continuous use can cause some adaptation in receptor sensitivity; cycling protocols (8 to 12 weeks on, 4 weeks off) are common.