- What is sermorelin and what does it do?
- Sermorelin is a 29-amino acid peptide that mimics the active fragment of natural growth hormone-releasing hormone (GHRH). It binds to GHRH receptors on the pituitary gland and stimulates the body's own pulsatile growth hormone release. The molecule was originally FDA-approved as Geref for pediatric GH deficiency. It is used in adult age-management practices to support GH levels that decline naturally with age. The sermorelin starter a licensed U.S. 503A compounding pharmacy compounds for Rx Peps Direct prescriptions is the 15 mg vial at $80 with a $39 medical review.
- Is sermorelin safe?
- Sermorelin has a long clinical safety record dating to the original Geref FDA approval in the 1990s. It works by stimulating endogenous GH release rather than supplying synthetic GH, so it preserves the body's negative feedback loop and avoids the supraphysiologic GH levels seen with HGH injections. The most commonly reported side effects are mild injection-site reactions, occasional flushing, and rare transient drowsiness. Sermorelin is contraindicated in patients with active malignancy, pituitary tumors, or active diabetic retinopathy.
- Does sermorelin work for adults with low growth hormone?
- Yes. Sermorelin reliably increases endogenous GH and IGF-1 levels in adults when dosed appropriately at bedtime. Clinical use over the last 3 decades supports improvements in body composition (reduced visceral fat, modest lean mass increase), sleep quality, and skin elasticity over a 3 to 6 month protocol. Effects are gentler than synthetic HGH because the body's pulsatile release pattern is preserved. In clinical studies, IGF-1 is the marker used to measure response; day to day, sleep, recovery, and body composition are the signals you and your clinician track.
- How much sermorelin should I take per day?
- The Rx Peps Direct starting dose is 20 units (0.6 mg) on a U-100 insulin syringe drawn from a 15 mg / 5 mL vial (3 mg/mL), taken subcutaneously once daily before bed. Some providers titrate to 1 mg per night based on your response and tolerance. Take it on an empty stomach (no food for 2 hours before) to avoid blunting the GH pulse with insulin or carbohydrate intake. Your provider will adjust the dose based on your response, side effects, and check-ins.
- Is sermorelin FDA approved?
- Sermorelin was FDA-approved as Geref in 1997 for diagnostic and pediatric use. The branded product was discontinued for commercial reasons, but sermorelin remains an FDA-listed active ingredient eligible for compounding by a 503A pharmacy under a patient-specific prescription. Rx Peps Direct prescribes sermorelin and the pharmacy compounds it under Section 503A; the Certificate of Analysis for every batch is published on this product page.
- Does sermorelin need to be refrigerated?
- Yes. Sermorelin ships pre-reconstituted from a licensed U.S. 503A compounding pharmacy and must be refrigerated at 36 to 46 degrees Fahrenheit (2 to 8 degrees Celsius). The pharmacy ships in cold-chain packaging to preserve potency in transit. Each vial carries a Beyond Use Date (BUD) that the pharmacy assigns and prints on the label. Once opened, keep the vial in the fridge and use it until it is empty or it reaches the date printed on its label, whichever comes first. Do not freeze; freezing degrades the peptide and reduces potency. Discard any vial past the date on the label.
- How do I get sermorelin prescribed?
- Complete the Rx Peps Direct intake at RxPepsDirect.com. The intake captures medical history, current medications, and your goals. A licensed nurse practitioner or physician assistant in your state reviews your intake; if sermorelin is appropriate they write the prescription. A licensed U.S. 503A compounding pharmacy fills it and ships via FedEx overnight, pre-reconstituted and ready to inject. The flat fee is $39 per order regardless of how many peptides are included.
