Sermorelin/Ipamorelin
Dual-pathway GH stimulation combining a GHRH analog with a selective ghrelin receptor agonist.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.What It Is
This combination pairs Sermorelin (GHRH analog) with Ipamorelin (ghrelin mimetic) in a single vial for convenience and synergistic GH stimulation.
How It Works
Sermorelin stimulates GHRH receptors while Ipamorelin activates ghrelin receptors. Two different pathways that together produce a stronger, more natural GH pulse.
Who It's For
Those wanting the benefits of both peptides in a single, convenient injection. Great for body composition and recovery goals.
Who Should Avoid It
Same as other GH secretagogues: avoid with active cancer, pituitary tumors.
Protocol & Pricing
OBP Pharmacy Price
$100/15mg+18mg
You pay pharmacy price. No markup.
Starting Dose
20 units (0.6mg/0.72mg)
Form
Injectable vial (5mL, 3mg-3.6mg/mL, 15mg+18mg total)
Dosing Protocol
20 units subcutaneous injection daily for 5 days, 2 days off. 20 units = 0.2mL × 3mg/mL = 0.6mg Sermorelin + 0.2mL × 3.6mg/mL = 0.72mg Ipamorelin per injection.
Beyond Use Date
90 Days from compounding (USP <797>)
Use within this window from the date your vial is compounded. BUD is set per USP <797> sterile compounding standards and printed on every label.
Stacking Guide
Stacks Well With
Related Peptides
Independently tested
Sermorelin/Ipamorelin lab test reports
Every Sermorelin/Ipamorelin batch dispensed by Optimal Balance Pharmacy is independently tested by Eagle Analytical Services (FDA-registered, A2LA ISO 17025 accredited) for sterility (ScanRDI) and bacterial endotoxin (USP <85>). The most recent report:
| Submission | Lot | Sample | Sterility | Endotoxin | |
|---|---|---|---|---|---|
| ETX-260123-0432 | 012326-12 | Sermorelin/Ipamorelin 3mg-3.6mg/ml (5ml) SIP1518 | Pass | Pass <2 EU/mL / 375 EU/mL | Download |
Eagle Analytical Services is an independent FDA-registered laboratory, A2LA accredited to ISO 17025, based in Houston, Texas. They have no commercial relationship with PeptideRx. PeptideRx prescribes; Optimal Balance Pharmacy compounds and dispenses; Eagle tests every batch. Three separate companies. Browse our full quality program on the quality page.
Common questions about Sermorelin/Ipamorelin
- What is the Sermorelin/Ipamorelin combo?
- Sermorelin/Ipamorelin is a compounded blend of two growth hormone secretagogues that work through complementary mechanisms. Sermorelin is a 29-amino acid GHRH analog that increases pituitary GH production. Ipamorelin is a selective ghrelin receptor agonist that triggers a clean GH pulse without raising cortisol or prolactin. Combined, they produce a stronger pulsatile GH release than either peptide alone, similar in concept to the CJC-1295/Ipamorelin pairing but using sermorelin (shorter half-life) rather than CJC-1295 (extended half-life).
- Is the combo better than either peptide alone?
- Each peptide stimulates a different receptor pathway, so the combined effect is additive rather than redundant. Combined GHRH + ghrelin agonist protocols generally produce stronger IGF-1 elevation than either peptide alone at equivalent doses. Sermorelin/Ipamorelin is often chosen over CJC-1295/Ipamorelin by patients who want a shorter-acting GHRH response that more closely mimics natural pulsatile release.
- How is Sermorelin/Ipamorelin dosed?
- Common protocols deliver 200 to 500 mcg of each peptide subcutaneously once daily before bed. Optimal Balance Pharmacy compounds the blend against PeptideRx prescriptions; the per-dose draw on your insulin syringe depends on the vial concentration printed on your label. Your provider sets the protocol based on your IGF-1 baseline.
- When and where should I inject the combo?
- Inject 30 minutes before bed on an empty stomach. Food (especially carbohydrates) blunts the GH pulse, so most providers recommend nothing to eat for 2 hours before. Subcutaneous injection into the abdomen, upper outer thigh, or back of the upper arm with a 31-gauge insulin syringe. Sterile syringes are included with every PeptideRx shipment.
- How is the combo supplied?
- Compounded by Optimal Balance Pharmacy under a 503A patient-specific prescription. Ships pre-reconstituted and ready to inject. Every batch is tested by Eagle Analytical Services for sterility (ScanRDI or Celsis) and bacterial endotoxin (USP <85>); the Certificate of Analysis is published on this product page.