5-Amino-1MQ

Common questions about 5-Amino-1MQ

What is 5-Amino-1MQ?

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that increases with obesity and aging. NNMT inhibition spares NAD+ and SAM (methyl donor) pools, increases adipocyte energy expenditure, and shifts metabolism toward fat oxidation. The molecule is investigational; most efficacy data is from animal models showing weight loss and improved metabolic markers.

Does 5-Amino-1MQ work for body composition?

Animal studies show consistent reductions in white-adipose tissue mass and improvements in metabolic markers when NNMT is inhibited. Human clinical trial data is limited; use is investigational and supervised by the prescribing provider. Patients commonly report mild changes in body composition over 8 to 12 weeks of consistent dosing rather than dramatic short-term effects.

How is 5-Amino-1MQ dosed?

Rx Peps Direct prescribes 5-Amino-1MQ as an injectable vial, not a capsule. Everyone starts at 20 units (0.2 mL of the 5 mg/mL vial, which is 1 mg) injected subcutaneously once daily. One vial holds 25 doses, so a fill is 1 vial, $80 at the pharmacy's price, and lasts 25 days. A course runs 8 to 12 weeks, then you re-evaluate with your prescriber. Take at least 4 weeks off before repeating. Your provider sets the dose and schedule for you, and the directions printed on your prescription label are the ones to follow.

Can I take a higher dose of 5-Amino-1MQ?

Yes, on request. A higher dose of 50 units (0.5 mL of the same 5 mg/mL vial, which is 2.5 mg) once daily is available. It is not a first-order choice: everyone starts at 1 mg. Once you have an approved order, your dashboard shows the higher dose. Ask for it there and your provider reviews and approves the change. Here is what the evidence shows. Research on 5-Amino-1MQ remains preclinical. Laboratory and animal studies show that inhibition of NNMT affects pathways involved in cellular energy balance and fat metabolism. Studies in diet-induced obese mice reported reductions in weight gain and fat mass after treatment with 5-Amino-1MQ. Human clinical trials have not established effectiveness, optimal dosing, or long-term safety. The dose used in this program therefore comes from the prescribing protocol rather than a published human clinical dosing study. The practical side is cost. At 2.5 mg a vial lasts 10 days, so a fill is 3 vials: $240 for 30 days, against $80 for 25 days at 1 mg.

How do I take 5-Amino-1MQ?

Subcutaneous injection into the abdomen, upper outer thigh, or back of the upper arm using a U-100 insulin syringe. Sterile syringes are included with every Rx Peps Direct shipment. Rotate sites between injections, and follow the directions printed on your prescription label.

How is 5-Amino-1MQ supplied?

Compounded by a licensed U.S. 503A compounding pharmacy under a patient-specific prescription as an injectable vial (5 mL at 5 mg/mL, 25 mg total) with a 90-day beyond-use date. It ships pre-reconstituted and ready to inject. Every batch is tested by Eagle Analytical Services for sterility (ScanRDI or Celsis) and bacterial endotoxin (USP <85>); the Certificate of Analysis is published on this product page. Follow the storage instructions and beyond-use date printed on your label.