FOXO4-DRI
A FOXO4 D-retro-inverso peptide that disrupts the FOXO4-p53 interaction in senescent cells, releasing p53 to trigger their selective apoptosis.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
What It Is
FOXO4-DRI is a modified (D-retro-inverso) fragment of the FOXO4 protein studied as a senolytic. Senescent cells accumulate with age and secrete inflammatory signals; FOXO4-DRI is designed to target them specifically while sparing healthy cells.
How It Works
In senescent cells, FOXO4 holds p53 in check to keep those cells alive. FOXO4-DRI competitively blocks the FOXO4-p53 interaction, freeing p53 to drive apoptosis selectively in senescent cells. Healthy cells, which do not rely on this interaction, are largely unaffected.
Who It's For
Adults focused on longevity and age-related cellular decline who want a provider-supervised senolytic protocol. Typically used in short, intermittent cycles rather than daily.
Who Should Avoid It
Not for active cancer or during pregnancy or breastfeeding. Limited long-term human data; provider supervision required. Discuss thoroughly with your provider.
Protocol & Pricing
OBP Pharmacy Price
$80/10mg
You pay pharmacy price. No markup.
Starting Dose
Per provider (cyclic senolytic protocol)
Form
Injectable vial (5mL, 2mg/mL, 10mg total)
Dosing Protocol
Provider-directed cyclic ("hit and run") senolytic dosing: short courses of consecutive days followed by an extended off period, not continuous daily use. 20 units = 0.2mL × 2mg/mL = 0.4mg per injection. Your provider sets the exact dose and cycle length.
Beyond Use Date
90 Days from compounding (USP <797>)
Optimal Balance Pharmacy assigns this date and prints it on your vial label. Always follow the label. Once a multi-dose vial is punctured, the in-use date on the label is shorter than the compounding date shown here.
Stacking Guide
Stacks Well With
Senolytic peptide (p53 / FOXO4 interaction blocker)
Read the FOXO4-DRI protocol guide
A D-retro-inverso peptide that kills senescent cells by freeing p53 from FOXO4 sequestration. Mouse results are real and peer-reviewed in Cell. There is no Phase 1 human trial, no human dose, and no human safety profile. Honest about that gap throughout.
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$100/75mgHow to get FOXO4-DRI prescribed online
FOXO4-DRI is available by prescription through a licensed telehealth visit and dispensed for human use by a named 503A pharmacy. That is what separates it from research-use-only vials sold without a prescription. There is no subscription and no membership, just a one-time visit fee.
- 1
Complete a $39 medical visit. Answer a short intake about your health history and your goals for FOXO4-DRI. The $39 fee is the only charge RxPepsDirect collects, paid once, not a recurring subscription.
- 2
A licensed provider reviews it. A US-licensed nurse practitioner or physician reviews your intake and, if FOXO4-DRI is appropriate for you, writes a patient-specific prescription. The starting dose is typically Per provider (cyclic senolytic protocol).
- 3
The pharmacy compounds and ships it. Optimal Balance Pharmacy, a 503A pharmacy in Texas, compounds FOXO4-DRI and ships it pre-reconstituted by FedEx overnight in a reusable cooled case. Your fill is Injectable vial (5mL, 2mg/mL, 10mg total), and you pay the pharmacy $80/10mg at wholesale, with no clinic markup, plus a $15 flat FedEx overnight shipping fee charged by the pharmacy.
RxPepsDirect prescribes FOXO4-DRI in the 29 jurisdictions its medical team is licensed in. Start a $39 visit or browse the full Longevity & Anti-Aging range. Comparing services first? See how RxPepsDirect stacks up against seven other providers in our best telehealth for compounded peptides comparison.
Common questions about FOXO4-DRI
- What is FOXO4-DRI?
- FOXO4-DRI is a modified (D-retro-inverso) fragment of the FOXO4 protein studied as a senolytic. Senescent cells accumulate with age and secrete inflammatory signals; FOXO4-DRI is designed to target them specifically while sparing healthy cells.
- How does FOXO4-DRI work?
- In senescent cells, FOXO4 holds p53 in check to keep those cells alive. FOXO4-DRI competitively blocks the FOXO4-p53 interaction, freeing p53 to drive apoptosis selectively in senescent cells. Healthy cells, which do not rely on this interaction, are largely unaffected.
- Who is FOXO4-DRI for?
- Adults focused on longevity and age-related cellular decline who want a provider-supervised senolytic protocol. Typically used in short, intermittent cycles rather than daily.
- How much does FOXO4-DRI cost?
- FOXO4-DRI costs $80/10mg from Optimal Balance Pharmacy at wholesale, with a flat $39 medical visit fee from RxPepsDirect. The form is Injectable vial (5mL, 2mg/mL, 10mg total).
- What is the Beyond Use Date for FOXO4-DRI?
- Optimal Balance Pharmacy assigns the Beyond Use Date for FOXO4-DRI and prints it on the vial label. The listed figure is 90 Days from compounding (USP <797>). Always follow the date on your own label, and note that once a multi-dose vial is punctured, the in-use date on the label is shorter than the compounding BUD.