A FOXO4 D-retro-inverso peptide that disrupts the FOXO4-p53 interaction in senescent cells, releasing p53 to trigger their selective apoptosis.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
Your prescriber
Kim Callender, NP, FNP-BC
Lead prescriber. Medical director: Jonathan Snipes, MD.
FOXO4-DRI lab report
Passed sterility and endotoxin
Tested by Eagle Analytical, lot LG342010838, report dated Sep 24, 2026.
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FOXO4-DRI is a modified (D-retro-inverso) fragment of the FOXO4 protein studied as a senolytic. Senescent cells accumulate with age and secrete inflammatory signals; FOXO4-DRI is designed to target them specifically while sparing healthy cells.
In senescent cells, FOXO4 holds p53 in check to keep those cells alive. FOXO4-DRI competitively blocks the FOXO4-p53 interaction, freeing p53 to drive apoptosis selectively in senescent cells. Healthy cells, which do not rely on this interaction, are largely unaffected.
Adults focused on longevity and age-related cellular decline who want a provider-supervised senolytic protocol. Typically used in short, intermittent cycles rather than daily.
Not for active cancer or during pregnancy or breastfeeding. Limited long-term human data; provider supervision required. Discuss thoroughly with your provider.
Ready to add FOXO4-DRI?
A licensed provider reviews every order.
Pharmacy Price
$80/10mg
You pay pharmacy price. No markup.
Starting Dose
Per provider (cyclic senolytic protocol)
Form
Injectable vial (5mL, 2mg/mL, 10mg total)
Dosing Protocol
Provider-directed cyclic ("hit and run") senolytic dosing: short courses of consecutive days followed by an extended off period, not continuous daily use. 20 units = 0.2mL × 2mg/mL = 0.4mg per injection. Your provider sets the exact dose and cycle length.
Beyond Use Date
90 Days from compounding (USP <797>)
A licensed U.S. 503A compounding pharmacy assigns this date and prints it on your vial label. Always follow the label.
Ready to add FOXO4-DRI?
A licensed provider reviews every order.
Ready to add FOXO4-DRI?
A licensed provider reviews every order.
Senolytic peptide (p53 / FOXO4 interaction blocker)
A D-retro-inverso peptide that kills senescent cells by freeing p53 from FOXO4 sequestration. Mouse results are real and peer-reviewed in Cell. There is no Phase 1 human trial, no human dose, and no human safety profile. Honest about that gap throughout.
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All 2 FOXO4-DRI samples tested for sterility and endotoxin passed both. Latest sample received by the lab Sep 22, 2026.
Every FOXO4-DRI batch dispensed by a licensed U.S. 503A compounding pharmacy is independently tested by Eagle Analytical Services (FDA-registered, A2LA ISO 17025 accredited). Sterility testing checks that nothing grows in the sample; the USP <85> endotoxin test checks for bacterial toxins that can cause fever. Below is the lab's own report for each of the 2 most recent lots.
Eagle Analytical Services is an independent FDA-registered laboratory, A2LA accredited to ISO 17025, based in Houston, Texas. They have no commercial relationship with Rx Peps Direct. Rx Peps Direct prescribes; the pharmacy compounds and dispenses; Eagle tests every batch. Three separate companies. Results apply only to the tested sample as received. Browse our full quality program on the quality page.
Ready to add FOXO4-DRI?
A licensed provider reviews every order.
FOXO4-DRI is available by prescription after an online medical review and dispensed for human use by a licensed 503A pharmacy. That is what separates it from research-use-only vials sold without a prescription. There is no membership, just a medical review fee per order, and automatic refills are optional.
Complete a $39 medical review. Answer a short intake about your health history and your goals for FOXO4-DRI. The $39 fee is the only charge Rx Peps Direct collects, paid once, not a recurring subscription.
A licensed provider reviews it. A US-licensed clinician reviews your intake and, if FOXO4-DRI is appropriate for you, writes a patient-specific prescription. The starting dose is typically Per provider (cyclic senolytic protocol).
The pharmacy compounds and ships it. A licensed 503A compounding pharmacy in Texas compounds FOXO4-DRI and ships it pre-reconstituted by FedEx overnight in a reusable cooled case. Your fill is Injectable vial (5mL, 2mg/mL, 10mg total), and you pay the pharmacy $80/10mg at wholesale, with no clinic markup, plus a $15 flat FedEx overnight shipping fee charged by the pharmacy.
Rx Peps Direct prescribes FOXO4-DRI in the 28 states plus Washington, DC where its medical team is licensed. Start your $39 medical review or browse the full Longevity & Anti-Aging range. Comparing services first? See how Rx Peps Direct stacks up against seven other providers in our best telehealth for compounded peptides comparison.
Ready to add FOXO4-DRI?
A licensed provider reviews every order.
Ready to add FOXO4-DRI?
A licensed provider reviews every order.