MOTS-C High-Dose
Higher-dose mitochondrial peptide for more intensive metabolic optimization.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
What It Is
The same MOTS-C peptide at a higher concentration for intensive metabolic optimization protocols.
How It Works
Same AMPK activation and metabolic regulation at higher concentrations for those on advanced longevity protocols.
Who It's For
Experienced users seeking intensive mitochondrial optimization. Provider-guided escalation.
Who Should Avoid It
Same as standard MOTS-C. Provider must approve escalation.
Protocol & Pricing
OBP Pharmacy Price
$130/50mg
You pay pharmacy price. No markup.
Starting Dose
20 units (2mg)
Form
Injectable vial (5mL, 10mg/mL, 50mg total)
Dosing Protocol
20 units subcutaneous injection 3 times per week (e.g. Monday, Wednesday, Friday), or on training days per provider. 20 units = 0.2mL × 10mg/mL = 2mg per injection.
Beyond Use Date
90 Days from compounding (USP <797>)
Use within this window from the date your vial is compounded. BUD is set per USP <797> sterile compounding standards and printed on every label.
Stacking Guide
Stacks Well With
Mitochondrial-derived peptide (metabolic)
Read the MOTS-C High-Dose protocol guide
Strong rodent data, thin human RCT data. AMPK activator (different mechanism than metformin). WADA prohibited since 1/1/2025. Not an exercise substitute.
Related Peptides
How to get MOTS-C High-Dose prescribed online
MOTS-C High-Dose is available by prescription through a licensed telehealth visit and dispensed for human use by a named 503A pharmacy. That is what separates it from research-use-only vials sold without a prescription. There is no subscription and no membership, just a one-time visit fee.
- 1
Complete a $39 medical visit. Answer a short intake about your health history and your goals for MOTS-C High-Dose. The $39 fee is the only charge RxPepsDirect collects, paid once, not a recurring subscription.
- 2
A licensed provider reviews it. A US-licensed nurse practitioner or physician reviews your intake and, if MOTS-C High-Dose is appropriate for you, writes a patient-specific prescription. The starting dose is typically 20 units (2mg).
- 3
The pharmacy compounds and ships it. Optimal Balance Pharmacy, a 503A pharmacy in Texas, compounds MOTS-C High-Dose and ships it pre-reconstituted by FedEx overnight in a reusable cooled case. Your fill is Injectable vial (5mL, 10mg/mL, 50mg total), and you pay the pharmacy $130/50mg at wholesale, with no clinic markup, plus a $15 flat FedEx overnight shipping fee charged by the pharmacy.
RxPepsDirect prescribes MOTS-C High-Dose in the 28 states its medical team is licensed in. Start a $39 visit or browse the full Longevity & Anti-Aging range.
Common questions about MOTS-C High-Dose
- What is the high-dose MOTS-c formulation?
- The high-dose MOTS-c formulation is a higher-concentration version of standard MOTS-c compounded by Optimal Balance Pharmacy for patients running more aggressive metabolic or athletic protocols. The active ingredient is identical; the formulation concentrates more peptide per mL to support larger per-dose amounts.
- When is the high-dose MOTS-c indicated?
- High-dose MOTS-c is typically chosen by experienced patients who have run standard MOTS-c protocols and want to step up to a stronger metabolic effect, or by athletic patients targeting endurance or metabolic flexibility outcomes that warrant higher per-dose amounts. New MOTS-c users should start at the standard formulation.
- How is high-dose MOTS-c dosed?
- Common protocols deliver 10 to 20 mg subcutaneously 2 to 3 times per week for 8 to 12 weeks at a time. Optimal Balance Pharmacy compounds the formulation against RxPepsDirect prescriptions; your provider sets the protocol on your shipment sheet. Your provider may pull baseline and follow-up metabolic labs (HbA1c, fasting insulin, lipid panel) to assess response.
- How do I inject the high-dose MOTS-c?
- Subcutaneously into the abdomen, upper outer thigh, or back of the upper arm using a 31-gauge insulin syringe. Sterile syringes are included with every RxPepsDirect shipment.
- How is high-dose MOTS-c supplied?
- Compounded by Optimal Balance Pharmacy under a 503A patient-specific prescription. Ships pre-reconstituted and ready to inject in cold-chain packaging. Every batch is tested by Eagle Analytical Services; the Certificate of Analysis is published on this product page.