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MOTS-C High-Dose

Higher-dose mitochondrial peptide for more intensive metabolic optimization.

Dr. Jonathan Snipes, MDMedically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
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MOTS-C High-Dose dispensed by a licensed U.S. 503A compounding pharmacy

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Intensive ProtocolHigher ConcentrationMetabolic OptimizationAdvanced

What It Is

The same MOTS-C peptide at a higher concentration for intensive metabolic optimization protocols.

How It Works

Same AMPK activation and metabolic regulation at higher concentrations for those on advanced longevity protocols.

Who It's For

Experienced users seeking intensive mitochondrial optimization. Provider-guided escalation.

Who Should Avoid It

Same as standard MOTS-C. Provider must approve escalation.

Ready to add MOTS-C High-Dose?

A licensed provider reviews every order.

Protocol & Pricing

Pharmacy Price

$130

10mg/mL, 5mL vial (50mg total)

You pay pharmacy price. No markup.

Starting Dose

20 units (2mg)

Form

Injectable vial, 5mL

Your pharmacy label will read

MOTs-C

10 MG/ML (5 ML)

The label shows strength per mL, not the total in the vial.

What that means

  • 10mg/mL means 10mg in every mL.
  • The vial holds 5mL, so 10mg/mL × 5mL = 50mg in the vial.
  • Each 20-unit injection (0.2mL) gives you 2mg, about 25 injections per vial.

Dosing Protocol

20 units subcutaneous injection 3 times per week (e.g. Monday, Wednesday, Friday), or on training days per provider. 20 units = 0.2mL × 10mg/mL = 2mg per injection.

Beyond Use Date

90 Days from compounding (USP <797>)

A licensed U.S. 503A compounding pharmacy assigns this date and prints it on your vial label. Always follow the label.

Ready to add MOTS-C High-Dose?

A licensed provider reviews every order.

Stacking Guide

Stacks Well With

NAD+ InjectableEpithalon

Ready to add MOTS-C High-Dose?

A licensed provider reviews every order.

Mitochondrial-derived peptide (metabolic)

Read the MOTS-C High-Dose protocol guide

Strong rodent data, thin human RCT data. AMPK activator (different mechanism than metformin). WADA prohibited since 1/1/2025. Not an exercise substitute.

Read guide

Related Peptides

NAD+ Injectable

The cellular energy molecule. Injectable NAD+ for direct bioavailability and cellular rejuvenation.

$100 · 100mg/mL, 10mL vial (1000mg total)

Epithalon

A telomerase-activating peptide that may help maintain telomere length. A key marker of cellular aging.

$80 · 2mg/mL, 5mL vial (10mg total)

Independently tested

MOTS-C High-Dose certificate of analysis

All 3 MOTS-C High-Dose samples tested for sterility and endotoxin passed both. Latest sample received by the lab Sep 29, 2026.

Every MOTS-C High-Dose batch dispensed by a licensed U.S. 503A compounding pharmacy is independently tested by Eagle Analytical Services (FDA-registered, A2LA ISO 17025 accredited). Sterility testing checks that nothing grows in the sample; the USP <85> endotoxin test checks for bacterial toxins that can cause fever. Below is the lab's own report for each of the 3 most recent lots.

Lot LG342010960, received Sep 29, 2026

Sterility
PassCelsis Sterility Test. Started Sep 29, 2026, completed Oct 7, 2026. Method suitability ETX-260112-0497
Bacterial endotoxin
PassUSP <85>. Measured <2 EU/mL, limit 1400 EU/mL. Started Oct 1, 2026, completed Oct 1, 2026
Sample, as printed
MOTs-C 10 MG/ML (5 ML) Injection
Lot #
LG342010960
Storage
Refrigerated
Received by lab
Sep 29, 2026
Laboratory
Eagle Analytical Services Inc., Houston, TX
Submission #
ETX-260929-0295
Signed
Alison Eng, Quality Control Manager
Scan of Eagle Analytical report ETX-260929-0295 for lot LG342010960. Opens the original PDF.
Eagle Analytical report ETX-260929-0295. Open the original PDF (opens in a new tab)

Eagle Analytical Services is an independent FDA-registered laboratory, A2LA accredited to ISO 17025, based in Houston, Texas. They have no commercial relationship with Rx Peps Direct. Rx Peps Direct prescribes; the pharmacy compounds and dispenses; Eagle tests every batch. Three separate companies. Results apply only to the tested sample as received. Browse our full quality program on the quality page.

Ready to add MOTS-C High-Dose?

A licensed provider reviews every order.

How to get MOTS-C High-Dose prescribed online

MOTS-C High-Dose is available by prescription after an online medical review and dispensed for human use by a licensed 503A pharmacy. That is what separates it from research-use-only vials sold without a prescription. There is no membership, just a medical review fee per order, and automatic refills are optional.

  1. 1

    Complete a $39 medical review. Answer a short intake about your health history and your goals for MOTS-C High-Dose. The $39 fee is the only charge Rx Peps Direct collects, paid once, not a recurring subscription.

  2. 2

    A licensed provider reviews it. A US-licensed clinician reviews your intake and, if MOTS-C High-Dose is appropriate for you, writes a patient-specific prescription. The starting dose is typically 20 units (2mg).

  3. 3

    The pharmacy compounds and ships it. A licensed 503A compounding pharmacy in Texas compounds MOTS-C High-Dose and ships it pre-reconstituted by FedEx overnight in a reusable cooled case. Your fill is a 5mL injectable vial at 10mg/mL (50mg total), labeled "MOTs-C 10 MG/ML (5 ML)", and you pay the pharmacy $130 per vial at wholesale, with no clinic markup, plus a $15 flat FedEx overnight shipping fee charged by the pharmacy.

Rx Peps Direct prescribes MOTS-C High-Dose in the 28 states plus Washington, DC where its medical team is licensed. Start your $39 medical review or browse the full Longevity & Anti-Aging range. Comparing services first? See how Rx Peps Direct stacks up against seven other providers in our best telehealth for compounded peptides comparison.

Ready to add MOTS-C High-Dose?

A licensed provider reviews every order.

Common questions about MOTS-C High-Dose

What is the high-dose MOTS-c formulation?
The high-dose MOTS-c formulation is a higher-concentration version of standard MOTS-c compounded by a licensed U.S. 503A compounding pharmacy for patients running more aggressive metabolic or athletic protocols. The active ingredient is identical; the formulation concentrates more peptide per mL to support larger per-dose amounts.
When is the high-dose MOTS-c indicated?
High-dose MOTS-c is typically chosen by experienced patients who have run standard MOTS-c protocols and want to step up to a stronger metabolic effect, or by athletic patients targeting endurance or metabolic flexibility outcomes that warrant higher per-dose amounts. New MOTS-c users should start at the standard formulation.
How is high-dose MOTS-c dosed?
Common protocols deliver 10 to 20 mg subcutaneously 2 to 3 times per week for 8 to 12 weeks at a time. A licensed U.S. 503A compounding pharmacy compounds the formulation against Rx Peps Direct prescriptions; your provider sets the protocol on your shipment sheet.
How do I inject the high-dose MOTS-c?
Subcutaneously into the abdomen, upper outer thigh, or back of the upper arm using a 31-gauge insulin syringe. Sterile syringes are included with every Rx Peps Direct shipment.
How is high-dose MOTS-c supplied?
Compounded by a licensed U.S. 503A compounding pharmacy under a patient-specific prescription. Ships pre-reconstituted and ready to inject in cold-chain packaging. Every batch is tested by Eagle Analytical Services; the Certificate of Analysis is published on this product page.

Ready to add MOTS-C High-Dose?

A licensed provider reviews every order.