Cashmere Cream (GHK-Cu 3% / Niacinamide 4%)
Combines GHK-Cu (collagen synthesis and ECM remodeling) with niacinamide (barrier repair, redness reduction, sebum regulation). The two actives are mechanistically complementary and chemically stable in the same vehicle.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
What It Is
A daily-use compounded face moisturizer with 3% GHK-Cu (30mg/g) and 4% niacinamide (40mg/g) in a hydrating cream base. At 3% GHK-Cu, this is approximately 30 to 60 times the concentration disclosed by leading OTC brands like The Ordinary (0.1%) and Biossance.
How It Works
Applied to clean skin morning or evening. GHK-Cu drives collagen and elastin synthesis through fibroblast signaling. Niacinamide reinforces the skin barrier, reduces transepidermal water loss, and dampens redness.
Who It's For
Adults seeking a daily anti-aging moisturizer at prescription concentration. Suitable for normal, dry, and combination skin. Niacinamide also helps with mild redness and post-inflammatory hyperpigmentation.
Who Should Avoid It
Known copper allergy. Avoid on broken skin. Discontinue if niacinamide flushing is persistent (uncommon at 4%).
Protocol & Pricing
OBP Pharmacy Price
$45/30gm
You pay pharmacy price. No markup.
Starting Dose
Pea-sized amount once or twice daily
Form
Topical cream (30g jar, GHK-Cu 30mg/g, Niacinamide 40mg/g)
Dosing Protocol
Apply a pea-sized amount to face and neck once or twice daily after cleansing. Layer under sunscreen in the morning. 30g jar covers approximately 60 to 90 days of twice-daily use.
Beyond Use Date
180 Days from compounding (USP <795>)
Optimal Balance Pharmacy assigns this date and prints it on your vial label. Always follow the label. Once a multi-dose vial is punctured, the in-use date on the label is shorter than the compounding date shown here.
Stacking Guide
Stacks Well With
Topical copper peptide protocol
Read the Cashmere Cream (GHK-Cu 3% / Niacinamide 4%) protocol guide
Why prescription compounded GHK-Cu (1 to 3 percent) outperforms The Ordinary, Biossance, and NIOD (0.05 to 0.1 percent). The seven topical peptides RxPepsDirect prescribes and how to pick between them.
Related Peptides
GHK-Cu Niacinamide Firm Boost Serum
Lightweight 3% GHK-Cu and 3% niacinamide serum for face and neck. Firming and barrier repair without the SNAP-8 layer.
$120/30mLGHK-Cu SNAP-8 Niacinamide Serum
Three-active serum: 3% GHK-Cu for collagen, 1% SNAP-8 for expression lines, 3% niacinamide for barrier repair. Lightweight aqueous vehicle.
$140/30mLHow to get Cashmere Cream (GHK-Cu 3% / Niacinamide 4%) prescribed online
Cashmere Cream (GHK-Cu 3% / Niacinamide 4%) is available by prescription through a licensed telehealth visit and dispensed for human use by a named 503A pharmacy. That is what separates it from research-use-only vials sold without a prescription. There is no subscription and no membership, just a one-time visit fee.
- 1
Complete a $39 medical visit. Answer a short intake about your health history and your goals for Cashmere Cream (GHK-Cu 3% / Niacinamide 4%). The $39 fee is the only charge RxPepsDirect collects, paid once, not a recurring subscription.
- 2
A licensed provider reviews it. A US-licensed nurse practitioner or physician reviews your intake and, if Cashmere Cream (GHK-Cu 3% / Niacinamide 4%) is appropriate for you, writes a patient-specific prescription. The starting dose is typically Pea-sized amount once or twice daily.
- 3
The pharmacy compounds and ships it. Optimal Balance Pharmacy, a 503A pharmacy in Texas, compounds Cashmere Cream (GHK-Cu 3% / Niacinamide 4%) and ships it ready to use in its dispensed form by FedEx overnight. Your fill is Topical cream (30g jar, GHK-Cu 30mg/g, Niacinamide 40mg/g), and you pay the pharmacy $45/30gm at wholesale, with no clinic markup, plus a $15 flat FedEx overnight shipping fee charged by the pharmacy.
RxPepsDirect prescribes Cashmere Cream (GHK-Cu 3% / Niacinamide 4%) in the 28 states its medical team is licensed in. Start a $39 visit or browse the full Skin & Hair range. Comparing services first? See how RxPepsDirect stacks up against seven other providers in our best telehealth for compounded peptides comparison.
Common questions about Cashmere Cream (GHK-Cu 3% / Niacinamide 4%)
- What is Cashmere Cream (GHK-Cu 3% / Niacinamide 4%)?
- A daily-use compounded face moisturizer with 3% GHK-Cu (30mg/g) and 4% niacinamide (40mg/g) in a hydrating cream base. At 3% GHK-Cu, this is approximately 30 to 60 times the concentration disclosed by leading OTC brands like The Ordinary (0.1%) and Biossance.
- How does Cashmere Cream (GHK-Cu 3% / Niacinamide 4%) work?
- Applied to clean skin morning or evening. GHK-Cu drives collagen and elastin synthesis through fibroblast signaling. Niacinamide reinforces the skin barrier, reduces transepidermal water loss, and dampens redness.
- Who is Cashmere Cream (GHK-Cu 3% / Niacinamide 4%) for?
- Adults seeking a daily anti-aging moisturizer at prescription concentration. Suitable for normal, dry, and combination skin. Niacinamide also helps with mild redness and post-inflammatory hyperpigmentation.
- How much does Cashmere Cream (GHK-Cu 3% / Niacinamide 4%) cost?
- Cashmere Cream (GHK-Cu 3% / Niacinamide 4%) costs $45/30gm from Optimal Balance Pharmacy at wholesale, with a flat $39 medical visit fee from RxPepsDirect. The form is Topical cream (30g jar, GHK-Cu 30mg/g, Niacinamide 40mg/g).
- What is the Beyond Use Date for Cashmere Cream (GHK-Cu 3% / Niacinamide 4%)?
- Optimal Balance Pharmacy assigns the Beyond Use Date for Cashmere Cream (GHK-Cu 3% / Niacinamide 4%) and prints it on the vial label. The listed figure is 180 Days from compounding (USP <795>). Always follow the date on your own label, and note that once a multi-dose vial is punctured, the in-use date on the label is shorter than the compounding BUD.