Cashmere Cream (GHK-Cu 3% / Niacinamide 4%)
Combines GHK-Cu (collagen synthesis and ECM remodeling) with niacinamide (barrier repair, redness reduction, sebum regulation). The two actives are mechanistically complementary and chemically stable in the same vehicle.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
What It Is
A daily-use compounded face moisturizer with 3% GHK-Cu (30mg/g) and 4% niacinamide (40mg/g) in a hydrating cream base. At 3% GHK-Cu, this is approximately 30 to 60 times the concentration disclosed by leading OTC brands like The Ordinary (0.1%) and Biossance.
How It Works
Applied to clean skin morning or evening. GHK-Cu drives collagen and elastin synthesis through fibroblast signaling. Niacinamide reinforces the skin barrier, reduces transepidermal water loss, and dampens redness.
Who It's For
Adults seeking a daily anti-aging moisturizer at prescription concentration. Suitable for normal, dry, and combination skin. Niacinamide also helps with mild redness and post-inflammatory hyperpigmentation.
Who Should Avoid It
Known copper allergy. Avoid on broken skin. Discontinue if niacinamide flushing is persistent (uncommon at 4%).
Protocol & Pricing
OBP Pharmacy Price
$45/30gm
You pay pharmacy price. No markup.
Starting Dose
Pea-sized amount once or twice daily
Form
Topical cream (30g jar, GHK-Cu 30mg/g, Niacinamide 40mg/g)
Dosing Protocol
Apply a pea-sized amount to face and neck once or twice daily after cleansing. Layer under sunscreen in the morning. 30g jar covers approximately 60 to 90 days of twice-daily use.
Beyond Use Date
180 Days from compounding (USP <797>)
Use within this window from the date your vial is compounded. BUD is set per USP <797> sterile compounding standards and printed on every label.
Stacking Guide
Stacks Well With
Topical copper peptide protocol
Read the Cashmere Cream (GHK-Cu 3% / Niacinamide 4%) protocol guide
Why prescription compounded GHK-Cu (1 to 3 percent) outperforms The Ordinary, Biossance, and NIOD (0.05 to 0.1 percent). The seven topical SKUs RxPepsDirect prescribes and how to pick between them.
Related Peptides
GHK-Cu Niacinamide Firm Boost Serum
Lightweight 3% GHK-Cu and 3% niacinamide serum for face and neck. Firming and barrier repair without the SNAP-8 layer.
$120/30mLGHK-Cu SNAP-8 Niacinamide Serum
Three-active serum: 3% GHK-Cu for collagen, 1% SNAP-8 for expression lines, 3% niacinamide for barrier repair. Lightweight aqueous vehicle.
$140/30mLCommon questions about Cashmere Cream (GHK-Cu 3% / Niacinamide 4%)
- What is Cashmere Cream (GHK-Cu 3% / Niacinamide 4%)?
- A daily-use compounded face moisturizer with 3% GHK-Cu (30mg/g) and 4% niacinamide (40mg/g) in a hydrating cream base. At 3% GHK-Cu, this is approximately 30 to 60 times the concentration disclosed by leading OTC brands like The Ordinary (0.1%) and Biossance.
- How does Cashmere Cream (GHK-Cu 3% / Niacinamide 4%) work?
- Applied to clean skin morning or evening. GHK-Cu drives collagen and elastin synthesis through fibroblast signaling. Niacinamide reinforces the skin barrier, reduces transepidermal water loss, and dampens redness.
- Who is Cashmere Cream (GHK-Cu 3% / Niacinamide 4%) for?
- Adults seeking a daily anti-aging moisturizer at prescription concentration. Suitable for normal, dry, and combination skin. Niacinamide also helps with mild redness and post-inflammatory hyperpigmentation.
- How much does Cashmere Cream (GHK-Cu 3% / Niacinamide 4%) cost?
- Cashmere Cream (GHK-Cu 3% / Niacinamide 4%) costs $45/30gm from Optimal Balance Pharmacy at wholesale, with a flat $39 medical visit fee from RxPepsDirect. The form is Topical cream (30g jar, GHK-Cu 30mg/g, Niacinamide 40mg/g).
- What is the Beyond Use Date for Cashmere Cream (GHK-Cu 3% / Niacinamide 4%)?
- 180 Days from compounding (USP <797>) BUDs are assigned per USP <797> sterile compounding standards and printed on every vial label.