GHK-Cu SNAP-8 Niacinamide Serum
Stacks three actives in a lightweight serum. GHK-Cu drives collagen synthesis and ECM remodeling. SNAP-8 inhibits SNARE-complex assembly (same target as botulinum toxin) to soften expression lines. Niacinamide reinforces the skin barrier and reduces redness.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
What It Is
A compounded prescription serum at 3% GHK-Cu, 1% SNAP-8 (acetyl octapeptide-3), and 3% niacinamide in an aqueous vehicle. SNAP-8 inhibits SNARE complex assembly extracellularly, the same protein complex botulinum toxin disables intracellularly. Effects accumulate over 4 to 12 weeks.
How It Works
Applied to clean face once or twice daily. Penetration is rapid because the vehicle is aqueous and lightweight. Layer Cashmere Cream or another moisturizer on top.
Who It's For
Patients targeting expression lines (forehead, between brows, around eyes) who want a topical alternative or adjunct to injectable Botox. Suitable for all skin types.
Who Should Avoid It
Known allergy to copper or any ingredient. Discontinue if persistent irritation. Patch test before full-face application.
Protocol & Pricing
OBP Pharmacy Price
$140/30mL
You pay pharmacy price. No markup.
Starting Dose
3 to 5 drops applied to face once or twice daily
Form
Topical serum (30mL bottle, GHK-Cu 30mg/mL, SNAP-8 10mg/mL, Niacinamide 30mg/mL)
Dosing Protocol
Apply 3 to 5 drops to face and neck once or twice daily after cleansing. Pat in gently. Layer moisturizer on top. 30mL bottle covers approximately 90 to 120 days. Initial softening of expression lines typically visible at 4 to 6 weeks; full effect at 12 weeks.
Beyond Use Date
180 Days from compounding (USP <797>)
Use within this window from the date your vial is compounded. BUD is set per USP <797> sterile compounding standards and printed on every label.
Stacking Guide
Stacks Well With
Do Not Combine With
Topical SNARE-inhibiting peptide
Read the GHK-Cu SNAP-8 Niacinamide Serum protocol guide
SNAP-8 targets the same SNARE complex botulinum toxin disables, but topically and gradually. Less potent than Botox; effects accumulate over 4 to 12 weeks. Available in two compounded formulations.
Related Peptides
Cashmere Cream (GHK-Cu 3% / Niacinamide 4%)
Compounded 3% GHK-Cu and 4% niacinamide daily moisturizer. 30 to 60 times the copper-peptide concentration of OTC serums.
$45/30gmGHK-Cu 1% Hair Restoration Solution
Compounded 1% GHK-Cu scalp solution. Tripeptide-copper complex for hair restoration and follicular support.
$100/30mLCommon questions about GHK-Cu SNAP-8 Niacinamide Serum
- What is GHK-Cu SNAP-8 Niacinamide Serum?
- A compounded prescription serum at 3% GHK-Cu, 1% SNAP-8 (acetyl octapeptide-3), and 3% niacinamide in an aqueous vehicle. SNAP-8 inhibits SNARE complex assembly extracellularly, the same protein complex botulinum toxin disables intracellularly. Effects accumulate over 4 to 12 weeks.
- How does GHK-Cu SNAP-8 Niacinamide Serum work?
- Applied to clean face once or twice daily. Penetration is rapid because the vehicle is aqueous and lightweight. Layer Cashmere Cream or another moisturizer on top.
- Who is GHK-Cu SNAP-8 Niacinamide Serum for?
- Patients targeting expression lines (forehead, between brows, around eyes) who want a topical alternative or adjunct to injectable Botox. Suitable for all skin types.
- How much does GHK-Cu SNAP-8 Niacinamide Serum cost?
- GHK-Cu SNAP-8 Niacinamide Serum costs $140/30mL from Optimal Balance Pharmacy at wholesale, with a flat $39 medical visit fee from RxPepsDirect. The form is Topical serum (30mL bottle, GHK-Cu 30mg/mL, SNAP-8 10mg/mL, Niacinamide 30mg/mL).
- What is the Beyond Use Date for GHK-Cu SNAP-8 Niacinamide Serum?
- 180 Days from compounding (USP <797>) BUDs are assigned per USP <797> sterile compounding standards and printed on every vial label.