Gonadorelin
A GnRH peptide that signals the pituitary to release LH and FSH, driving endogenous testosterone and gonadal function.
Medically reviewed by Dr. Jonathan Snipes, MD. Last reviewed May 6, 2026.
What It Is
Gonadorelin is synthetic GnRH (gonadotropin-releasing hormone). On testosterone therapy it is used to maintain testicular function and fertility that exogenous testosterone otherwise suppresses, a role historically filled by hCG.
How It Works
It acts on the pituitary to release LH and FSH, which drive testicular or ovarian function and your own testosterone. The critical principle is pulsatility: GnRH naturally pulses, so intermittent dosing stimulates the axis while continuous exposure downregulates it. Frequency is set carefully for that reason.
Who It's For
Men on TRT who want to preserve testicular size and fertility markers, and patients on physician-directed fertility protocols. Requires hormone monitoring.
Who Should Avoid It
Avoid in pregnancy. Discuss any hormone-sensitive condition or pituitary disorder with your prescriber before starting. Coordinate with any testosterone, hCG, estrogen, or fertility treatment, and monitor LH, FSH, and testosterone or estradiol. Prohibited in tested sport under the WADA Prohibited List.
Protocol & Pricing
OBP Pharmacy Price
$35/1mg
You pay pharmacy price. No markup.
Starting Dose
Per provider (2 to 3 times weekly)
Form
Injectable vial (5mL, 200mcg/mL, 1mg total)
Dosing Protocol
Provider-set units 2 to 3 times weekly on a 200 mcg/mL vial (dosed in micrograms; e.g. 10 units = 20 mcg). Pulsatile, intermittent dosing maintains the LH/FSH stimulus; do not dose continuously.
Beyond Use Date
90 Days from compounding (USP <797>)
Use within this window from the date your vial is compounded. BUD is set per USP <797> sterile compounding standards and printed on every label.
Stacking Guide
Stacks Well With
Related Peptides
Common questions about Gonadorelin
- What is Gonadorelin?
- Gonadorelin is synthetic GnRH (gonadotropin-releasing hormone). On testosterone therapy it is used to maintain testicular function and fertility that exogenous testosterone otherwise suppresses, a role historically filled by hCG.
- How does Gonadorelin work?
- It acts on the pituitary to release LH and FSH, which drive testicular or ovarian function and your own testosterone. The critical principle is pulsatility: GnRH naturally pulses, so intermittent dosing stimulates the axis while continuous exposure downregulates it. Frequency is set carefully for that reason.
- Who is Gonadorelin for?
- Men on TRT who want to preserve testicular size and fertility markers, and patients on physician-directed fertility protocols. Requires hormone monitoring.
- How much does Gonadorelin cost?
- Gonadorelin costs $35/1mg from Optimal Balance Pharmacy at wholesale, with a flat $39 medical visit fee from RxPepsDirect. The form is Injectable vial (5mL, 200mcg/mL, 1mg total).
- What is the Beyond Use Date for Gonadorelin?
- 90 Days from compounding (USP <797>) BUDs are assigned per USP <797> sterile compounding standards and printed on every vial label.